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Belimumab in systemic lupus erythematosus
  1. Andreia Vilas-Boas1,
  2. Sandra A Morais1 and
  3. David A Isenberg2
  1. 1Internal Medicine Department, Hospital Pedro Hispano, Matosinhos, Portugal
  2. 2Centre for Rheumatology, University College London Hospitals, London, UK
  1. Correspondence to David A Isenberg; d.isenberg{at}


Systemic lupus erythematosus (SLE) is one of the most challenging autoimmune disorders with a complex pathophysiology and diverse clinical presentation. Many drugs have been used to treat SLE with suboptimal results, especially in patients with moderate-to-severe disease. Belimumab is the first biological drug to be approved for the treatment of SLE in more than 50 years. This monoclonal antibody blocks B-cell activating factor, a cytokine important for B-cell differentiation and survival. In this review we focus on the activity of belimumab in patients with SLE and discuss the controversies of its use.

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  • Received January 21, 2015.
  • Accepted February 11, 2015.
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