Introduction Long-term glucocorticoid therapy is the leading cause of secondary osteoporosis. The management of glucocorticoid-induced osteoporosis (GIOP) seems to be inadequate in many European countries.
Objective To evaluate the rate of screening and treatment of GIOP.
Design Information was collected from a national public health-insurance database in our geographic area of Provence-Alpes-Côte-d'Azur and in Corsica, from September 2009 through August 2011.
Patients We identified participants aged 15 years and over starting glucocorticoid therapy (≥7.5 mg of prednisone equivalent per day during at least 90 days consecutive). This cohort was compared with an age-matched and sex-matched population that did not receive glucocorticoids.
Main outcome measures Bone mass, prescription of bone antiresorptive medication and use of calcium and/or vitamin D treatment.
Results We identified 32 812 patients who were prescribed glucocorticoid therapy, yielding 1% prevalence. Incidence of glucocorticoid therapy was 2.8/1000 inhabitants/year. Males represented 44%, the mean age was 58 years. The median prednisone-equivalent dose was 11 mg/day (IQR 9–18 mg/day). 8% underwent bone mass measurement. Calcium and/or vitamin D, and bisphosphonates were prescribed in 18% and 12%, respectively. Results were lower for the control population: 3% underwent bone mass measurement and 3% received bisphosphonate therapy. The rates of osteodensitometry and treatments were higher in women over 55 years of age than in men and women 55 years of age and younger, and also when glucocorticoid therapy was initiated by a rheumatologist versus other physician specialty.
Conclusions The management of GIOP remains very inadequate, despite the availability of a statutory health insurance system. Targeted interventions are needed to improve the management of GIOP.
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What is already known about this subject?
Long-term glucocorticoid therapy is common and is the leading cause of secondary osteoporosis.
What does this study add?
Information from a national public health-insurance database confirm that management of glucocorticoid- induced osteoporosis is currently inadequate.
How might this impact on clinical practice?
Primary care physicians should be better informed of their crucial role in prevention and management glucocorticoid-induced osteoporosis.
Long-term glucocorticoid therapy is the leading cause of secondary osteoporosis. Glucocorticoids are widely prescribed, with about 0.5–1.2% of adults in the general population being on long-term glucocorticoid therapy,1–3 and this prevalence increases with age. Glucocorticoid prescriptions have actually increased between 1989 and 2008 in UK.3 Glucocorticoid-induced osteoporosis (GIOP) has been associated with substantial morbidity related to major fracture. The relative risk of fracture is significantly increased even at low glucocorticoid dosages.4 ,5 Glucocorticoids decrease bone formation and increase bone resorption, which, 3 months after the beginning of treatment, leads to bone fragility.6 The main causes for being on glucocorticoid therapy are inflammatory rheumatic diseases, lung disorders and inflammatory bowel diseases.3 The underlying inflammation for which glucocorticoids are used also influenced bone fragility—bone loss is related to inflammation.7
Management of GIOP is not optimal worldwide.8 Many countries have issued national recommendations for minimising the risk of GIOP via both primary prevention at treatment initiation and secondary prevention in patients with pre-existing osteoporosis. An example is the set of guidelines developed by the American College of Rheumatology in 2001 and updated in 2010.9 ,10 Specifically in France, prevention of GIOP must be considered as soon as possible in men and women for whom corticosteroid therapy equivalent to ≥7.5 mg prednisone daily for ≥3 months is scheduled. In these patients, osteodensitometry (dual-energy X-ray absorptiometry, DXA) and daily calcium 1500 mg and vitamin D 800 UI are recommended. Pharmacological treatment is indicated for those with a history of fragility fracture or, if absent, in those with T-score <−1.5 SD.11 ,12 These recommendations changed lately.13
Unfortunately, there is abundant evidence from various countries that the management of GIOP remains suboptimal, but data from France are lacking.
We hypothesised that the management of GIOP was less than ideal in our region of France (Provence-Alpes-Côte-d'Azur and Corsica). To assess this hypothesis, we used claims data from the statutory health insurance system, to evaluate the rate of detection and treatment of GIOP. DXA is not mandatory and is insufficient to assess bone fragility in GIOP. In French 2003 recommendations, only menopausal women with fragility fracture should be prescribed with antiosteoporotic drugs without DXA. For all other cases (men, women before menopause, women after menopause without fragility fracture) DXA measurement is required. So DXA measurement is tightly associated with the physician implication in GIOP management.
We used the claims database of the French statutory health insurance system, which covers most past and present salaried workers, and the unemployed, and their families, that is, about 4.1 million individuals and 83% of the population, in our geographic area of Provence-Alpes-Côte-d'Azur and Corsica. The data were extracted by health insurance physicians in the region. None of the extracted data contained information on patient or physician identity.
The following data were collected: coded identifiers of the patient and prescribing physician, sociodemographic information on the patient and prescribing physician, details on the delivery of glucocorticoids and other medications of interest, and whether DXA was performed. Prescribing physicians’ specialty was available in the databases except for those working in publicly funded hospitals; for our study, their specialties were therefore recorded as unknown. As the study databases were de-identified, patient informed consent was not required.
Among the individuals in the database, those aged 15 years or over who had at least two prescriptions for glucocorticoids filled between 1 September 2009 and 31 August 2011, were identified. Then, we selected those individuals with prescriptions for oral therapy with prednisone, prednisolone, methylprednisolone, betamethasone and/or dexamethasone. The next step was selecting patients with prescriptions of at least a 7.5 mg prednisone-equivalent per day for at least 90 consecutive days (prevalent cases of long-term glucocorticoid therapy). Finally, we identified the incident cases of long-term glucocorticoid therapy, defined as those prevalent cases who did not fill glucocorticoid prescriptions during the first 6 months of the 24-month study period. Thus, patients younger than 15 years, taking non-oral route glucocorticoids, taking a prednisone-equivalent dosage lower than 7.5 mg/day, with glucocorticoid treatment duration shorter than 90 days, or with glucocorticoid prescription filled during the first 6 months of the study period, were not included. Each incident case was matched on age and sex to a control, defined as an individual in the database who had no filled oral glucocorticoid prescriptions during the study period.
In the cases, we collected the following data: age, sex, daily glucocorticoid dosage, glucocorticoid treatment duration, specialty of the first physician to prescribe glucocorticoid therapy and reason for glucocorticoid therapy (defined as the chronic disease status granted by the health insurance system in response to a request from the primary care physician).
We used administrative data to compare rates of bone mass measurement evaluated by DXA, and osteoporosis treatment in cases and controls between 1 September 2009 and 31 August 2011. For this study, osteoporosis treatments were defined as calcium associated with vitamin D supplements (which could be separately given as oral solution or fixed combination with alendronate, for instance) and as any of the following osteoporosis medications: bisphosphonates, raloxifene, teriparatide and strontium ranelate. Our list of osteoporosis medications did not include calcitonin and oestrogens, as they are not approved for the treatment of osteoporosis in France.
Qualitative variables were described using number (%) and quantitative variables using mean±SD when distribution was normal and median (IQR) otherwise. Kaplan-Meier curves were plotted to estimate glucocorticoid treatment duration.
To identify variables independently associated with DXA and osteoporosis treatment, we built a multivariate logistic regression model and computed the adjusted ORs (aORs). The variables we used were sex, age, specialty of glucocorticoid prescriber, mean dosage, underlying diagnosis and DXA prescription. Treatments were analysed as three categories: calcium associated with vitamin D; bisphosphonates (the other osteoporosis medications being in very small amounts); and any treatment, that is, calcium, vitamin D and/or any osteoporosis treatment drug. We performed χ2 tests and Fisher tests on categorical variables. Statistical tests (χ2 tests and Fisher tests) on categorical variables were performed. To evaluate whether dosage of prednisone of prednisone influenced the rate of bisphosphonates prescription, we split the prednisone dosage in five classes (7.5–10; 10–15; 15–20, 20–30 and more than 30 mg) and conducted a χ2 test for trend.
Of the 3.3 million individuals aged at least 15 years in the database, 518 853 had at least two glucocorticoid prescriptions filled during the study period, including 32 812 with filled prescriptions in a dosage of at least 7.5 mg/day and for at least 90 consecutive days, yielding a prevalence of 1% of longstanding glucocorticoid therapy (figure 1). Of these 32 812 patients, 14 205 (43%) met our definition of incident cases, yielding an incidence of 0.4% for 18 months in the overall population aged at least 15 years, corresponding to an incidence of long-term glucocorticoid therapy of 2.8/1000 inhabitants/year (assuming that incidence rate is constant during the study).
Of the 14 205 cases, 6311 (44%) were males and 7894 (55%) females, including 4377 (31%) females older than 55 years. Mean age was 58±19 years overall, 58±18 years were males and 57±20 years were females. Median glucocorticoid dosage was 11 mg/day (IQR 9–18 mg/day) of prednisone equivalent and varied very little with age and sex. Median glucocorticoid treatment duration was 206 days (95% CI 202 to210 days).
Prescriptions of absorptiometry and treatments
DXA was performed during the study period in 1175 (8%) cases and 251 (3%) controls (p<10−6). Osteoporosis treatments (vitamin D and/or calcium and/or osteoporosis medications (bisphosphonates, raloxifene, teriparatide, strontium ranelate)) were prescribed in combination with glucocorticoid therapy in 36% of cases and 11% of controls (p<10−6). Prescribed supplements were distributed as follows: calcium, 20% of cases and 5% of controls (p<10−6); vitamin D, 32% and 11% (p<10−6); and both, 18% and 4% (p<10−6). Bisphosphonate therapy was prescribed in 12% of cases and 3% of controls (p<10−6). Other osteoporosis medications rate was very low: 1.7% of cases used ranelate, 0.2% teriparatide and 0.5% raloxifene. Table 1 reports details on DXA, supplements and osteoporosis medications prescription.
Prescribers and reasons for prescription of glucocorticoid therapy
The first glucocorticoid prescription filled by the cases was prescribed by primary care physicians in 55% of cases, rheumatologists in 5%, pulmonologists in 2%, gastroenterologists in 2% and internists in 1% of cases. Prescriber's specialty was unknown in 23% of cases, suggesting that glucocorticoid therapy was initiated at a public hospital (on an inpatient or outpatient basis). The main underlying health conditions associated with glucocorticoid prescriptions were rheumatoid arthritis (20%); autoimmune disease defined as systemic lupus erythematosus, polyarteritis nodosa or Sjögren's syndrome (13%); chronic respiratory failure (13%); asthma (10%); and chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis, 8%).
Factors associated with prescription of absorptiometry and osteoporosis treatment
By multivariate analysis, variables showing independent positive associations with DXA were female gender (aOR 5.1) (p<10−6), age older than 55 years (aOR 3.9) (p<10−6) and glucocorticoid therapy initiated by a rheumatologist (aOR 3.9) (p<10−6). These results are detailed in table 2. The highest DXA prescription rate, found in women older than 55 years treated by rheumatologists, only reached 39% (table 3).
Similarly, prescription of osteoporosis treatment showed independent positive associations with female gender, age older than 55 years, initiation of glucocorticoid therapy by a rheumatologist, autoimmune disease as the underlying diagnosis and prescription of DXA (tables 1 and 2 and see online supplementary table S4). There was a significant dose effect in prescription of bisphosphonates by dosage of prednisone. The results showed a significant linear increase of probability of treatment by bisphosphonate with the increase of prednisone dosage (respectively 7%, 12%, 16%, 19% and 21% for the corresponding classes of prednisone dosage 7.5–10; 10–15; 15–20, 20–30 and more than 30 mg). At least one osteoporosis treatment (osteoporosis medication and/or calcium and vitamin D) was prescribed to 58% of women over 55 years of age and 26% of men. Rates of calcium associated with vitamin D supplement prescription ranged from 15% among primary care physicians to 37% among gastroenterologists, rates of bisphosphonate prescription from 10% among primary care physicians to 28% among rheumatologists and rates of prescription of any osteoporosis treatment from 31% among primary care physicians to 65% among rheumatologists. At least one osteoporosis treatment was prescribed in 80% of cases with autoimmune diseases, 36% of cases with asthma and 36% of cases overall. The rate of calcium associated with vitamin D supplement prescription ranged from 16% in cases with asthma to 58% in those with autoimmune disease, and the rate of bisphosphonate prescription ranged from 5% in patients with chronic inflammatory bowel disease to 41% in those with autoimmune disease.
In the group with DXA prescription, the proportions of patients with prescriptions for calcium associated with vitamin D supplements, bisphosphonates and any treatment were 47%, 35% and 79%, respectively; corresponding proportions in the group without DXA prescription were 15%, 10% and 32%. The rate of prescription of any osteoporosis treatment was highest (81%) among women older than 55 years with DXA prescription and lowest (20%) in men whose glucocorticoid treatment had been initiated by a primary care physician.
Our study population can be considered as a representative sample of the French population and our data confirm our hypothesis that the management of GIOP is suboptimal, despite the existence of published recommendations. The 1% prevalence of long-term glucocorticoid therapy was consistent with previous studies showing prevalence of 0.5–0.9% overall, and of up to 2.5% in the 70–79 year age group.1–3 Although DXA and osteoporosis treatment prescription rates were substantially higher among the cases than among the controls, they were markedly inadequate. Despite a mean prednisone-equivalent dosage of 11 mg/day, only 8% of cases underwent DXA and only 25% were prescribed calcium associated with vitamin D supplements, 19% a bisphosphonate and 45% any treatment. In women older than 55 years—the group at highest risk—only 19% underwent DXA and only 58% were prescribed an osteoporosis treatment. Corresponding rates in men were 3% and 26%.
Our findings are consistent overall with those obtained previously in various countries.1 ,2 ,14–26 The DXA prescription rates in our population are in line with several published studies reporting rates of about 6% in men and women younger than 50 years of age and of up to 16%–19% in women older than 50 years of age.15 ,22 ,23 The low DXA prescription rate is of concern, since DXA showed the strongest association with treatment prescription, with an aOR of 4.6. The role of DXA as a trigger for treatment to prevent or control osteoporosis has been well established.22 In France, DXA is widely available, as it can be performed by rheumatologists and radiologists. DXA costs €40 and is almost fully reimbursed, so it cannot explain the low rate of individuals with a DXA measurement.
In previously published studies that also confined the analysis to incident cases of glucocorticoid therapy, the rates of calcium associated with vitamin D supplementation were not recorded.26–28 Other studies analysed all glucocorticoid-treated patients and found calcium associated with vitamin D supplementation rates ranging from 30% to 51%. These higher rates compared with our results may be ascribable to methodological differences.14 ,16 ,22 ,25 A study of incident cases showed lower bisphosphonate prescription rates than in our population, of 8% overall and 16% in women over 55 years, compared with 12% and 24% in our study, respectively. Another study of all patients given glucocorticoid therapy also found a slightly lower rate, of 7%.20 ,23 The rates of prescription of any treatment in our study are difficult to compare to previously published data, since we excluded oestrogen therapy from our list of osteoporosis medications. In studies that included oestrogen replacement therapy, rates of prescription of any treatment ranged from 21% to 58%, compared with 36% in our population.14 ,17 ,20 ,23 ,24
In our study, treatment prescription rates were associated with the specialty of the physician who initiated glucocorticoid therapy and with the underlying diagnosis. Treatment prescription rates were highest when the initial prescriber was a rheumatologist, with 25% of patients receiving DXA and 65% treatment prescriptions; and when the underlying diagnosis was an autoimmune disease (systemic lupus erythematosus, Sjögren's syndrome, or polyarteritis nodosa). When specified, better management of GIOP by rheumatologists was consistently found.15 ,21 ,23
One of the strengths of our study lies in the collection of data from an entire population as opposed to a sample. In France, 75% of individuals are covered by a single statutory health insurance system. In addition, in patients who have chronic diseases, this health insurance system reimburses the full cost of both, DXA and treatments (including the supplements and medications of interest in our study). Thus, there are no financial obstacles to adequate management, and all filled prescriptions are recorded in the health insurance database. Out-of-pocket purchases of treatments (including calcium and vitamin D supplements) are extremely uncommon. Another strong point of our study is that only incident cases of glucocorticoid therapy were included in the analysis. The bone loss induced by glucocorticoids occurs early and at a fast pace, being significant within 6 months. Consequently, an evaluation of bone risk and the implementation of prophylactic measures should take place at, or shortly after, the first prescription of glucocorticoid therapy.
Our study also exhibits some weaknesses. First, the database had no information on the specialties of physicians working in publicly funded hospitals, who comprised 22% of initial glucocorticoid prescribers. This point explains the small proportion of internists in our study, as most internists work full-time in hospitals. Initial glucocorticoid therapy prescription by a hospital-based physician was associated with slightly higher prescription rates of supplements and osteoporosis medications, compared with initial prescription by a community-based physician. Second, the data were anonymised and we had no information allowing us to determine which individuals met criteria for the prescription of antiresorptive therapy. Indeed, we had no information on osteoporosis risk factors such as body mass index, family or personal history of fracture, nor on fall risk factors such as comorbidity and living conditions. However, the rate of calcium-associated vitamin D prescription should have been close to 100% but was only 18%, despite a mean patient age of 58 years and a mean daily prednisone-equivalent dosage of 11 mg.
Targeted interventions are required in order to improve GIOP. A simple mailing intervention programme that screened at-risk patients and reached out to these patients and their physicians was associated with a modest increase in the proportion of at-risk patients receiving preventive drug therapy for osteoporosis.29 Online educational video did not improve the prescription of preventive drug therapy for osteoporosis.30 ,31 Pharmacists could be involved to inform patients and physicians. However, active identification of patients eligible for GIOP by pharmacists did not significantly increase the prescribing of bisphosphonates in a randomised trial.32 New tools should be developed to improve physician and patient concerns about GIOP. It would be of interest to develop medications that associate corticosteroids with antiosteoporotic drugs. New French GIOP guidelines have recently been published,13 we hope this will improve GIOP management.
The results of our study conducted in 2009–2011 in a population of a large region of France are consistent with those of all other published international studies: the management of GIOP remains very inadequate, despite the availability of a statutory health insurance system. Inadequacies are particularly marked among primary care physicians, who comprise the largest proportion of initial glucocorticoid prescribers and play a crucial role in patient follow-up. In addition, we have no information on adherence to delivered treatments. Our data indicate a pressing need for targeted interventions designed to improve the management of GIOP.
- Received January 15, 2016.
- Revision received May 9, 2016.
- Accepted May 12, 2016.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement Unpublished data can be obtained by contacting the corresponding author.
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