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Original article
Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts
  1. Max Yates1,2,
  2. Richard Watts2,3,
  3. Ingeborg Bajema4,
  4. Maria Cid5,
  5. Bruno Crestani6,
  6. Thomas Hauser7,
  7. Bernhard Hellmich8,
  8. Julia Holle9,
  9. Martin Laudien10,
  10. Mark A Little11,
  11. Raashid Ahmed Luqmani12,
  12. Alfred Mahr13,
  13. Peter Merkel14,
  14. John Mills15,
  15. Janice Mooney1,
  16. Mårten Segelmark16,
  17. Vladimir Tesar17,
  18. Kerstin W A Westman18,
  19. Augusto Vaglio19,
  20. Nilüfer Yalçındağ20,
  21. David R Jayne21 and
  22. Chetan Mukhtyar1
  1. 1Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich, UK
  2. 2Norwich Medical School, Bob Champion Research and Education Building, Colney Lane, Norwich, UK
  3. 3Department of Rheumatology, Ipswich Hospital NHS Trust, Norwich Medical School, Norwich, UK
  4. 4Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
  5. 5Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  6. 6Assistance Publique-Hôpitaux de Paris, Department of Pulmonology, Bichat-Claude Bernard University Hospital, Paris, France
  7. 7Immunologie-Zentrum Zürich, Zürich, Switzerland
  8. 8Vaskulits-Zentrum Süd, Klinik für Innere Medizin, Rheumatologie und Immunologie, Medius Klinik Kirchheim, Kirchheim-Teck, Germany
  9. 9Rheumazentrum Schleswig-Holstein Mitte, Kuhberg 5a-7, Neumünster, Germany
  10. 10Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Kiel, Germany
  11. 11Trinity Health Kidney Centre, Tallaght Hospital, Dublin, Ireland
  12. 12Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK
  13. 13Department of Internal Medicine, Hôpital Saint-Louis, Université Paris 7 René Diderot, Paris, France
  14. 14Division of Rheumatology and the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  15. 15Vasculitis UK, West Bank House, Winster, Matlock, UK
  16. 16Department of Medical and Health Sciences Nephrology, Linköping University, Linköping, Sweden
  17. 17Department of Nephrology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
  18. 18Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö, Sweden
  19. 19Nephrology Unit, University Hospital of Parma, Parma, Italy
  20. 20Department of Ophthalmology, School of Medicine, Ankara University, Ankara, Turkey
  21. 21Lupus and Vasculitis Unit, Addenbrooke's Hospital, Cambridge, UK
  1. Correspondence to Dr Max Yates, Norwich Medical School; maxyates{at}doctors.org.uk

Abstract

The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted on by members of a learned society. This paper explores the wider validity of the recommendations among people who self-identify as clinicians caring for patients with vasculitis. In addition to the task force, a learned society (European Vasculitis Society—EUVAS) was invited, through online survey, to rate independently the strength of evidence of each recommendation to obtain an indication of the agreement among the final target audience and ultimate end-users of the recommendations. The survey took place in June 2015. Of the 158 EUVAS members surveyed, there were 88 responses (55.7%). There was a large degree of agreement in the voting patterns between EUVAS survey participants and task force members. Notable exceptions were lower grades for the recommendation of the use of rituximab for remission induction in patients with eosinophilic granulomatosis with polyangiitis and for methotrexate and mycophenolate mofetil as remission maintenance agents in patients with granulomatosis with polyangiitis/microscopic polyangiitis by EUVAS members. These results are encouraging and suggest that the voting patterns of the task force are representative of the wider vasculitis community. We recommend future recommendations adopt this approach for data/expert-based treatment guidelines, especially for multisystem diseases.

  • ANCA-associated vasculitis
  • Recommendations
  • Survey
  • Received February 2, 2017.
  • Revision received March 14, 2017.
  • Accepted March 21, 2017.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Key messages

  • The results reveal a large degree of agreement in the voting patterns among EUVAS members who responded to the survey and the members of the task force.

  • The generalisability of the findings is strengthened because the survey members derive from 29 countries from around the world.

  • One noted exception was the lower grade of recommendation for the use of rituximab in patients with EGPA amongst EUVAS survey responders.

Introduction

The European League Against Rheumatism (EULAR) recommendations for the management of small-vessel and medium-vessel vasculitides were recently updated, with a focus on antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis, and were coendorsed by the European Renal Association-European Dialysis and Transplant Association and European Vasculitis Society (EUVAS).1 The process for formation of such recommendations follows a standard methodology.2 3 Since ANCA-associated vasculitis can present to physicians from a wide range of specialities, a task force was convened with representation from different subspecialisations.

Standard practice for voting on the recommendations was followed but, for the first time, they were also voted on by members of a learnt society, which in this case was the EUVAS. EUVAS allows members to join the Society from around the world and as such is an open collaboration of physicians which aims to promote research and education in vasculitis.

Results from the Canadian Vasculitis Network revealed significant variations in practice highlighting the need for evidence-based management recommendations for ANCA-associated vasculitis.4 In addition, the publication of large collaborative trials, involving patients with ANCA-associated vasculitis, has advanced the evidence from which conclusions on treatment can be drawn.

This paper explores the wider validity of the recommendations among people who self-identify as clinicians caring for patients with vasculitis.

Methods

Developing the recommendations

Systematic review of several medical literature databases was used to identify clinical trials relevant for the purposes of developing the recommendations. Standardised procedures were followed in line with guidance from EULAR with evidence from clinical trials graded from A (highest—from at least one randomised controlled trial) to D (lowest—expert opinion).2 3 This evidence informed the development of statements. Finally, voting took place with individuals giving a strength of recommendation to the individual statements. Each task force member had a single independent vote for each statement. Strengths of recommendation are in part constrained by the category of evidence used to inform each statement.

Design

Wider validity exercise

In addition to the task force, a learnt society (EUVAS) was invited to rate independently the strength of evidence of each recommendation to obtain an indication of the agreement among the final target audience and ultimate end-users of the recommendations. Members of the task force whom were also members of EUVAS did not vote twice.

EUVAS membership

EUVAS is an open collaboration of physicians interested in research and education in vasculitis and evolved from the European Vasculitis Study Group. EUVAS is a non-political, non-profit organisation with a primary objective to unite researchers and clinicians to promote the study and treatment of vasculitis. Five of the task force members form the current presidential council (DRJ, KWAW, IB, TH and AM). Membership to EUVAS is subject to approval by the presidential council after written application. Ordinary membership is open to any clinician or scientist with a specific interest in the field of vasculitis. Associate membership is available to other individuals or institutions sharing an interest in vasculitis. There are 158 members of EUVAS from 28 different countries across Europe and across the globe.

Sampling frame

The EUVAS membership was emailed and invited to take part in an online survey. Non-responders were sent a second invitation to encourage uptake.

Analysis

Tables of the spread of results, in this case the strength of recommendation, for each statement were constructed with the most popular (mode) presented first.

Results

The survey took place in June 2015. The first email message was sent on 4 June 2015 with a link to an online survey. Two reminder emails were sent on 9 and 22 June. Of the 158 EUVAS members surveyed there were 88 responses (55.7%). The members were from 29 countries, distributed across the continents of Asia, Europe, North America, Oceania and South America.

The most popular (mode) vote was considered the grade of recommendation with the corresponding median also presented (table 1).

The results reveal a high degree of concordance between the task force and EUVAS survey votes. Lower grades of recommendation by the EUVAS survey occurred for the use of rituximab (D vs C) in patients with eosinophilic granulomatosis with polyangiitis (EGPA) suffering new-onset ANCA-associated vasculitis (AAV) and for maintenance therapy regimens using methotrexate or mycophenolate mofetil (B vs A). In non-organ, non-life threatening ANCA-associated vasculitis, no task force members voted grade A for use of methotrexate or mycophenolate in such situations, compared with 35% and 12% of the EUVAS group choosing these as options, respectively.

The task force also voted in a greater proportion for grade C than the EUVAS group for either methotrexate or mycophenolate for remission maintenance (35% vs 30% and 31%, respectively, for the EUVAS votes). Although both the task force and EUVAS voting patterns spread across the strengths of recommendation for methotrexate and mycophenolate mofetil, there was much greater agreement for the use of azathioprine for remission maintenance therapy in AAV, reflecting favouring azathioprine as the agent of choice in such situations.

Discussion

The results reveal a large degree of agreement in the voting patterns among EUVAS members who responded to the survey and the members of the task force. These results are encouraging and suggest that the voting patterns of the task force are representative of the wider vasculitis community. In addition, the generalisability of the findings is strengthened due to the distribution of countries from which the survey participants derive with representations from 29 countries around the world. However, the EUVAS group is likely to be a more research interested and active group compared with all clinicians who care for patients with AAV. We hope that the recommendations are adopted by all involved in the care of patients with AAV and draw attentions to the first statement. The purpose of surveying the EUVAS membership was to check that the task force did not hold widely different views.

There were key exceptions with lower grades of recommendation for the use of rituximab in patients with EGPA among EUVAS survey participants. The reasons for this small discrepancy are unclear but may reflect EUVAS members' familiarity with the previous recommendations in which rituximab was assigned as grade 4 evidence.5 The large rituximab in ANCA-associated vasculitis trial (RAVE) and rituximab versus cyclophosphamide in ANCA-associated vasculitis (RITUXVAS) trials did not include participants with EGPA and, generally, trials of agents used to treat patients with EGPA are of smaller size. In addition, most of the trials involving patients with EGPA included those with relapsing or refractory disease states. In addition, many disease-specific consequences of EGPA, such as asthma, are very glucocorticoid responsive making extrapolations from other medications used to treat other types of AAV difficult. This may have contributed to a lower grade being recommended by the EUVAS membership.

None of the task force considered a grade ‘A’ vote for mycophenolate mofetil, given appropriate situations, for remission induction. Indeed, the EULAR recommendations list a careful set of situations when these agents can be considered in non-organ, non-life-threatening presentations of AAV.1

The survey revealed the task force voted grade A recommendation for methotrexate or mycophenolate mofetil as remission-induction agents, the strength of agreement was low (53%). The EUVAS survey revealed a grade B vote. However, a greater proportion of task force members voted for grade C in such scenarios compared with the EUVAS survey members (35% vs 15%). This may represent a loss in confidence in these two drugs in the practising community as compared with the results of the clinical trials that were interpreted by the task force.

Table 1

Recommendation statements

Acknowledgments

We thank the patients, clinicians and administrative staff who have improved the standard of knowledge and care of patients with AAV, through well thought-out clinical trials.

  • Received February 2, 2017.
  • Revision received March 14, 2017.
  • Accepted March 21, 2017.

References

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View Abstract

Footnotes

  • Contributors MY drafted the manuscript. All authors have contributed to editing the drafts of the paper.

  • Funding MY is a recipient of a Clinical Research PhD Fellowship from Arthritis Research UK.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data from this survey are available from the corresponding author on request.

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