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Rheumatoid arthritis
Review
Synovial fibroblasts in 2017
  1. Caroline Ospelt
  1. Department of Rheumatology, Center of Experimental Rheumatology, University Hospital and University of Zurich, Zurich, Switzerland
  1. Correspondence to Dr Caroline Ospelt; Caroline.Ospelt{at}usz.ch

Abstract

Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in rheumatoid arthritis (RA). Furthermore, epigenetic changes in RA synovial fibroblasts and studies that focused on the identification of different subsets of synovial fibroblasts are discussed.

  • rheumatoidarthritis
  • fibroblasts
  • inflammation

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/rmdopen-2017-000471

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    Footnotes

    • Contributors CO planned and wrote the manuscript.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.