RT Journal Article
SR Electronic
T1 Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
JF RMD Open
JO RMD Open
FD EULAR
SP e000442
DO 10.1136/rmdopen-2017-000442
VO 3
IS 2
A1 Pauline Baudart
A1 Karine Louati
A1 Christian Marcelli
A1 Francis Berenbaum
A1 Jérémie Sellam
YR 2017
UL http://rmdopen.bmj.com/content/3/2/e000442.abstract
AB Objectives We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated.Methods We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA.Results From 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001).Conclusion The risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype.