PT  - JOURNAL ARTICLE
AU  - Philip J Mease
AU  - Dafna D Gladman
AU  - Ahmed S Samad
AU  - Laura C Coates
AU  - Lyrica X H Liu
AU  - Girish A Aras
AU  - David H Collier
AU  - James B Chung
TI  - Design and rationale of the Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis (SEAM-PsA)
AID  - 10.1136/rmdopen-2017-000606
DP  - 2018 Feb 01
TA  - RMD Open
PG  - e000606
VI  - 4
IP  - 1
4099  - http://rmdopen.bmj.com/content/4/1/e000606.short
4100  - http://rmdopen.bmj.com/content/4/1/e000606.full
SO  - RMD Open2018 Feb 01; 4
AB  - Objective To evaluate the efficacy of etanercept and methotrexate as monotherapies and as combination therapy in subjects with active psoriatic arthritis (PsA).Methods The Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis (SEAM-PsA) is an ongoing, global, double-blind, 48-week, randomised, controlled study. Subjects are randomised (1:1:1) to etanercept monotherapy, methotrexate monotherapy or etanercept-methotrexate combination therapy. Endpoints include rates of ACR20 response and Minimal Disease Activity, measures to characterise extra-articular manifestations (dactylitis, enthesitis, nail disease) and safety.Conclusion SEAM-PsA will characterise the effects of etanercept with and without background methotrexate and methotrexate alone on PsA manifestations, and provide information of practical importance to clinicians on the optimal treatment of PsA.