TY - JOUR T1 - Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999–2015). TREND-AR study JF - RMD Open JO - RMD Open DO - 10.1136/rmdopen-2018-000671 VL - 4 IS - 1 SP - e000671 AU - Ramón Mazzucchelli AU - Elia Pérez Fernandez AU - Natalia Crespí-Villarías AU - Javier Quirós-Donate AU - Alberto García Vadillo AU - María Espinosa AU - Marina Peña AU - Cristina Macía-Villa AU - Jose Luis Morell-Hita AU - Cristina Martinez-Prada AU - Virginia Villaverde AU - Inmaculada Morado Quiroga AU - Olalla Guzón-Illescas AU - Carmen Barbadillo AU - Manuel Fernández Prada AU - Hilda Godoy AU - Angela Herranz Varela AU - María Galindo Izquierdo AU - Gil Rodriguez Caravaca Y1 - 2018/06/01 UR - http://rmdopen.bmj.com/content/4/1/e000671.abstract N2 - Purpose To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years).Methods This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714.0 to 714.9 and HF 820.0 to 820.3. The crude and age-adjusted incidence rate of HF was calculated by age and sex strata over the last 17 years. General lineal models were used to analyse trends.Results Between 1999 and 2015, 6656 HFs occurred in patients with RA of all ages (84.25% women, mean age 77.5 and 15.75% men, mean age 76.37). The age-adjusted osteoporotic HF rate was 221.85/100 000 RA persons/ year (women 227.97; men 179.06). The HF incidence rate increased yearly by 3.1% (95% CI 2.1 to 4.0) during the 1999–2015 period (p<0.001) and was more pronounced in men (3.5% (95% CI 2.1 to 4.9)) than in women (3.1% (95% CI 2.3 to 4.1)). The female to male ratio decreased from 1.54 in 1999 to 1.14 in 2015. The average length of hospital stays (ALHS) decreased (p<0.001) from 16.76 days (SD 15.3) in 1999 to 10.78 days (SD 7.72) in 2015. Age at the time of hospitalisation increased (p<0.001) from 75.3 years (SD 9.33) in 1999 to 79.92 years (SD 9.47) in 2015. There was a total of 326 (4.9%) deaths during admission, 247 (4.4%) in women and 79 (7.5%) in men (p<0.001).Conclusion In Spain, despite the advances that have taken place in controlling disease activity and in treating osteoporosis, the incidence rate of HF increased in both male and female patients with RA. ER -