RT Journal Article
SR Electronic
T1 Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999–2015). TREND-AR study
JF RMD Open
JO RMD Open
FD EULAR
SP e000671
DO 10.1136/rmdopen-2018-000671
VO 4
IS 1
A1 Ramón Mazzucchelli
A1 Elia Pérez Fernandez
A1 Natalia Crespí-Villarías
A1 Javier Quirós-Donate
A1 Alberto García Vadillo
A1 María Espinosa
A1 Marina Peña
A1 Cristina Macía-Villa
A1 Jose Luis Morell-Hita
A1 Cristina Martinez-Prada
A1 Virginia Villaverde
A1 Inmaculada Morado Quiroga
A1 Olalla Guzón-Illescas
A1 Carmen Barbadillo
A1 Manuel Fernández Prada
A1 Hilda Godoy
A1 Angela Herranz Varela
A1 María Galindo Izquierdo
A1 Gil Rodriguez Caravaca
YR 2018
UL http://rmdopen.bmj.com/content/4/1/e000671.abstract
AB Purpose To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years).Methods This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714.0 to 714.9 and HF 820.0 to 820.3. The crude and age-adjusted incidence rate of HF was calculated by age and sex strata over the last 17 years. General lineal models were used to analyse trends.Results Between 1999 and 2015, 6656 HFs occurred in patients with RA of all ages (84.25% women, mean age 77.5 and 15.75% men, mean age 76.37). The age-adjusted osteoporotic HF rate was 221.85/100 000 RA persons/ year (women 227.97; men 179.06). The HF incidence rate increased yearly by 3.1% (95% CI 2.1 to 4.0) during the 1999–2015 period (p<0.001) and was more pronounced in men (3.5% (95% CI 2.1 to 4.9)) than in women (3.1% (95% CI 2.3 to 4.1)). The female to male ratio decreased from 1.54 in 1999 to 1.14 in 2015. The average length of hospital stays (ALHS) decreased (p<0.001) from 16.76 days (SD 15.3) in 1999 to 10.78 days (SD 7.72) in 2015. Age at the time of hospitalisation increased (p<0.001) from 75.3 years (SD 9.33) in 1999 to 79.92 years (SD 9.47) in 2015. There was a total of 326 (4.9%) deaths during admission, 247 (4.4%) in women and 79 (7.5%) in men (p<0.001).Conclusion In Spain, despite the advances that have taken place in controlling disease activity and in treating osteoporosis, the incidence rate of HF increased in both male and female patients with RA.