Comparison of JIA core criteria,† scores and clinical parameters at baseline and at 12-month FU
| Enrolment | 12-month FU | |
|---|---|---|
| JIA core criteria† | ||
| Active joint count, median, IQR | 2, 1–4 | 0, 0–1* |
| Active joint count=0, n (%) | 118 (17.0) | 456 (65.7)* |
| Limited ROM joint count, median, IQR | 2, 1–4 | 0, 0–2* |
| Limited ROM joint count=0, n (%) | 128 (18.7) | 366 (53.9)* |
| Physician's global assessment of disease activity, NRS, median, IQR | 3.5, 1.0–5.0 | 0.5, 0.0–1.5* |
| Physician's global assessment of disease activity=0 | 52 (7.5) | 290 (41.9)* |
| Parent's global assessment of well-being, median, IQR | 2.5, 1.0–4.0 | 1.0, 0.5–2.0* |
| Parent's global assessment of well-being=0 | 74 (10.7) | 190 (28.7)* |
| CHAQ, median, IQR | 0.4, 0.0–1.0 | 0.0, 0.0–0.4* |
| CHAQ=0, n (%) | 211 (30.5) | 382 (57.6)* |
| ESR, mm/h, median, IQR | 15.0, 8.0–31.0 | 9.0, 5.0–15.0* |
| ESR≤20 mm/h, n (% of tested) | 363 (62) | 376 (83.6) |
| CRP, mg/L, median, IQR | 2.5, 0.4–8.5 | 0.6, 0.1–2.8* |
| CRP≤5 mg/L, n (% of tested) | 417 (65.1) | 413 (86.0) |
| Active enthesitis, n (%) | 55 (8.0) | 17 (2.5) |
| History of uveitis, n (%) | 59 (8.5) | 82 (11.8) |
| JADAS3-10, median, IQR | 9.0, 5.0–14.0 | 2.0, 0.5–5.0* |
| JADAS3-10≤1, n (%) | 42 (6.1) | 264 (40.0)* |
| PedsQL, median, IQR parent | 71.7, 56.5–84.8 | 89.1, 77.4–95.7* |
| PedsQL, median, IQR patient | 78.3, 66.3–89.1 | 91.3, 80.4–97.8* |
| Pain, NRS, median, IQR | 2.0, 0.5–5.0 | 0.5, 0.0–2.0* |
| Pain=0, n (%) | 143 (20.8) | 308 (46.5)* |
| Inactive disease according to 2004 criteria by Wallace et al10 (%) | 40 (6.8) | 375 (54.0)* |
| Continuously inactive for 3 months according to 2004 criteria by Wallace et al10 (%) | – | 276 (39.7) |
| Remission on medication according to 2004 criteria by Wallace et al10 (%) | – | 183 (26.3) |
| Inactive disease according to 2011 criteria by Wallace et al13 (%) | 37 (6.1) | 363 (52.2) |
| Remission on medication according to 2011 criteria by Wallace et al13 (%) | – | 181 (26.0) |
*p<0.001.
†JIA core criteria: Defined according to Giannini et al.9
CHAQ, Child Health Assessment Questionnaire, 0–3; CRP: C reactive protein, cut-off for normal values: ≤5 mg/L; FU, follow-up; ESR: erythrocyte sedimentation rate; cut-off for normal values: ≤20 mm/h; JADAS3-10, Juvenile Arthritis Disease Activity Score 3–10, 0–30; JIA, JIA, juvenile idiopathic arthritis; NRS, numeric rating scale; PedsQL: Paediatric Quality of Life Inventory, 0–100; ROM, range of motion.