The change of SHS from BL to year 1 and year 2, and from year 1 to 2, among early RA patients with low, moderate and high MBDA scores, CRP and DAS28 at multiple time-points
| Disease activity time-point | Time-period for ΔSHS | ΔSHS mean (median) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MBDA score | p Value | CRP (mg/L) | p Value | DAS28 | p Value | ||||||||
| Panel (A) | Low (<30) | Moderate (30–44) | High (>44) | Low (≤10) | Moderate (>10–30) | High (>30) | Low (≤3.2) | Moderate (>3.2–5.1) | High (>5.1) | ||||
| Month 3 | BL–year 1 (n=205) | 0.5 (0) | 2.4 (1) | 4.8 (3) | <0.001 | 2.2 (0) | 4.0 (3) | 8.2 (4.5) | 0.004 | 2.2 (0.5) | 2.7 (1) | 5.1 (1) | 0.417 |
| BL–year 2 (n=205) | 1.5 (0) | 3.6 (2) | 7.2 (4.5) | <0.001 | 3.5 (1) | 6.1 (4.5) | 12.3 (6) | <0.001 | 3.7 (1) | 3.9 (2) | 8.0 (3) | 0.238 | |
| Year 1 | Year 1–2 (n=133) | 0.5 (0) | 1.0 (0) | 4.7 (3.0) | 0.004 | 1.1 (0) | 4.1 (2.5) | 8.7 (3) | 0.024 | 0.8 (0) | 1.9 (0) | 6.9 (3) | 0.074 |
| Panel (B) | Low | p Value | Moderate | p Value | High | p Value | |||||||
| MBDA | CRP | DAS28 | MBDA | CRP | DAS28 | MBDA | CRP | DAS28 | |||||
| Month 3 | BL–year 1 (n=205) | 0.5 (0) | 2.2 (0) | 2.2 (0.5) | 0.029 | 2.4 (1) | 4.0 (3) | 2.7 (1) | 0.665 | 4.8 (3) | 8.2 (4.5) | 5.1 (1) | 0.199 |
| BL–year 2 (n=205) | 1.5 (0) | 3.5 (1) | 3.7 (1) | 0.037 | 3.6 (2) | 6.1 (4.5) | 3.9 (2) | 0.336 | 7.2 (4.5) | 12.3 (6) | 8.0 (3) | 0.167 | |
| Year 1 | Year 1–2 (n=133) | 0.5 (0) | 1.1 (0) | 0.8 (0) | 0.883 | 1.0 (0) | 4.1 (2.5) | 1.9 (0) | 0.048 | 4.7 (3.0) | 8.7 (3) | 6.9 (3) | 0.890 |
p Values defined by Kruskal-Wallis test.
BL, baseline; CRP, C reactive protein; DAS, disease activity score; MBDA, multibiomarker disease activity; RA, rheumatoid arthritis; SHS, Sharp/van der Heijde score.