Domains and number of corresponding outcome measurement instruments in PsA randomised controlled trials, longitudinal observational studies and registries in 2010–2015
| Studies assessing each domain n (%) | ||||||
|---|---|---|---|---|---|---|
| 2006 PsA core domain set | Domains | Outcome measures Number/domain | Randomised controlled trials (N=22) | Longitudinal observational studies (N=27) | Registries (N=12) | Overlap with patient PsAID domains |
| Inner circle | Pain | 8 | 22 (100) | 18 (66.7) | 8 (66.7) | Yes |
| Peripheral joint activity | 14 | 21 (95.4) | 24 (88.9) | 10 (83.3) | No | |
| Physical function | 8 | 20 (90.9) | 21 (77.8) | 11 (91.7) | Yes | |
| Skin | 15 | 19 (86.4) | 19 (70.4) | 5 (41.7) | Yes | |
| Patient global | 9 | 18 (81.8) | 20 (74.1) | 10 (83.3) | No | |
| HRQL | 10 | 17 (77.3) | 14 (51.8) | 7 (58.3) | No | |
| Outer circle | ‘Acute phase reactants’ | 2 | 22 (100) | 20 (74.1) | 10 (83.3) | No |
| Physician global | 10 | 18 (81.8) | 13 (48.1) | 7 (58.3) | No | |
| Enthesitis | 10 | 13 (59.1) | 12 (44.4) | 3 (25.0) | No | |
| Dactylitis | 5 | 13 (59.1) | 12 (44.4) | 1 (8.3) | No | |
| Fatigue | 10 | 7 (35) | 12 (44.4) | 4 (33.3) | Yes | |
| Nail | 8 | 5 (22.7) | 8 (29.6) | 1 (8.3) | No | |
| Spine | 11 | 4 (20) | 9 (33.3) | 5 (41.7) | No | |
| ‘Radiology’ | 10 | 6 (27.3) | 6 (22.2) | 2 (16.7) | No | |
| Research agenda | ‘MRI/CT/US’ | 9 | 4 (20) | 4 (14.8) | 1 (8.3) | No |
| Participation | 3 | 1 (4.5) | 1 (3.7) | 0 | Yes | |
| ‘Tissue analysis’ | 0 | 0 | 0 | 0 | No | |
| Other domains not in the core set | Productivity | 15 | 7 (31.8) | 5 (18.5) | 4 (33.3) | Yes |
| Stiffness | 4 | 4 (18.2) | 4 (14.8) | 1 (8.3) | No | |
| Anxiety | 1 | 2 (9.1) | 1 (3.7) | 0 (0) | Yes | |
| Depression | 2 | 2 (9.1) | 2 (7.4) | 0 (0) | Yes | |
| Coping | 2 | 1 (4.5) | 0 | 0 | Yes | |
| Well-being | 1 | 1 (4.5) | 0 | 0 | No | |
| Self-efficacy | 1 | 0 | 1 (3.7) | 0 | No | |
| Sleep | 1 | 0 | 1 (3.7) | 0 | Yes | |
Domains are listed in decreasing order of frequency of their assessment in PsA randomised controlled trials. The original unabbreviated version of this table is listed as online supplementary table S2a and contains the complete list of all outcome measurement instruments used to assess each domain.
HRQL, health-related quality of life; PsA, psoriatic arthritis; PsAID, Psoriatis Arthritis Impact of Disease; US, ultrasound.