Univariable and multivariable logistic regression analysis for patients with and without any medical intervention
| Univariable OR (95% CI) | p Value | Multivariable OR (95% CI) | p Value | |
|---|---|---|---|---|
| Sociodemographics | ||||
| Age, years, mean (SD) | 1.02 (0.99 to 1.04) | 0.241 | 1.00 (0.98 to 1.03) | 0.823 |
| Female, N (%) | 1.05 (0.40 to 2.72) | 0.925 | 1.36 (0.50 to 3.70) | 0.554 |
| Disease duration, years, median (IQR) | 1.01 (0.96–1.06) | 0.699 | ||
| Onset of RP, years, median (IQR) | 1.01 (0.98–1.04) | 0.623 | ||
| Onset of non-RP, years, median (IQR) | 1.02 (0.97–1.07) | 0.471 | ||
| Disease characteristics, N (%) | ||||
| DcSSc | 1.05 (0.48 to 2.28) | 0.904 | ||
| DU | 2.59 (0.96 to 7.02) | 0.061 | ||
| Telangiectasia | 2.19 (1.05 to 4.54) | 0.036 | 2.27 (1.08 to 4.80) | 0.031 |
| Synovitis | 2.04 (0.46 to 9.11) | 0.351 | ||
| Friction rubs | 0.54 (0.10 to 2.77) | 0.456 | ||
| Proximal muscular weakness | 2.50 (0.32 to 19.73) | 0.385 | ||
| Pulmonary crackles | 1.73 (0.71 to 4.18) | 0.226 | ||
| MRSS, median (IQR) | 1.08 (0.99–1.18) | 0.081 | ||
| Anti-Scl-70 antibody | 1.44 (0.59 to 3.56) | 0.426 | ||
| Anticentromere antibody | 0.65 (0.30 to 1.40) | 0.271 | ||
| Diagnostic investigations | ||||
| ESR, mm, median (IQR) | 1.04 (1.01–1.07) | 0.013 | 1.04 (1.01–1.07) | 0.012 |
| CRP, mg/dL, median (IQR) | 1.06 (0.96–1.16) | 0.246 | ||
| CPK, mg/dL, median (IQR) | 1.00 (1.00–1.00) | 0.743 | ||
| Vital capacity % of predicted, mean (SD) | 0.99 (0.97 to 1.01) | 0.266 | ||
| NSIP according HRCT, N (%) | 1.80 (0.74 to 4.37) | 0.195 | ||
| CPET; maximum VO2% of predicted, mean (SD) | 0.99 (0.97 to 1.00) | 0.061 | ||
CPET, cardiopulmonary exercise test; CPK, creatine phosphokinase; CRP, C reactive protein; DcSSc, diffuse cutaneous SSc; DU, digital ulcers; ESR, erythrocyte sedimentation rate; MRSS, modified Rodnan Skin Score; NSIP, non-specific interstitial pneumonia; VO2 max, maximum volume oxygen.