Table 3

Radiological progression of joints at 2 years according to presence of baseline tenderness or synovitis and when tenderness and synovitis analysed together

			Radiological progression
	Presence	Number of joints	Number of joints	OR (95% CI)	p Value
Tenderness vs synovitis, analysed independently
Tender	No	1263	88 (7.5%)	1.53 (1.02 to 2.29)	0.039
Tender	Yes	625	72 (11.9%)	1.53 (1.02 to 2.29)	0.039
Clinical synovitis	No	1101	68 (6.6%)	2.08 (1.39 to 3.11)	<0.001
Clinical synovitis	Yes	784	91 (12.1%)	2.08 (1.39 to 3.11)	<0.001
B-mode synovitis	No	939	53 (5.9%)	1.64 (1.08 to 2.47)	0.019
B-mode synovitis	Yes	939	106 (12.1%)	1.64 (1.08 to 2.47)	0.019
PDUS synovitis	No	1410	91 (6.9%)	1.80 (1.2 to 2.71)	0.005
PDUS synovitis	Yes	468	68 (15%)	1.80 (1.2 to 2.71)	0.005
Tenderness and synovitis analysed together
Tenderness with no synovitis
Tender+No clinical synovitis	No	1685	145 (9.2%)	0.72 (0.42 to 1.22)	0.220
Tender+No clinical synovitis	Yes	202	15 (7.6%)	0.72 (0.42 to 1.22)	0.220
Tender+No B-mode synovitis	No	1657	138 (8.9%)	1.32 (0.69 to 2.55)	0.401
Tender+No B-mode synovitis	Yes	226	22 (10%)	1.32 (0.69 to 2.55)	0.401
Tender+No PDUS synovitis	No	1507	126 (8.9%)	1.11 (0.67 to 1.84)	0.671
Tender+No PDUS synovitis	Yes	376	34 (9.3%)	1.11 (0.67 to 1.84)	0.671
Tenderness with synovitis
Tender+clinical synovitis	No	1465	103 (7.5%)	1.89 (1.25 to 2.85)	0.002
Tender+clinical synovitis	Yes	422	57 (14%)	1.89 (1.25 to 2.85)	0.002
Tender+B-mode synovitis	No	1489	110 (7.9%)	1.44 (0.90 to 2.30)	0.124
Tender+B-mode synovitis	Yes	394	50 (13.1%)	1.44 (0.90 to 2.30)	0.124
Tender+PDUS synovitis	No	1639	122 (7.9%)	1.73 (1.07 to 2.80)	0.026
Tender+PDUS synovitis	Yes	244	38 (16%)	1.73 (1.07 to 2.80)	0.026
Absence of tenderness and synovitis
Not tender+no clinical synovitis	No	987	106 (11.2%)	0.57 (0.39 to 0.82)	0.003
Not tender+no clinical synovitis	Yes	899	53 (6.4%)	0.57 (0.39 to 0.82)	0.003
Not tender+no B-mode synovitis	No	1170	128 (11.6%)	0.45 (0.29 to 0.72)	<0.001
Not tender+no B-mode synovitis	Yes	713	31 (4.6%)	0.45 (0.29 to 0.72)	<0.001
Not tender+no PDUS synovitis	No	849	102 (12.4%)	0.52 (0.35 to 0.77)	0.001
Not tender+no PDUS synovitis	Yes	1034	57 (6%)	0.52 (0.35 to 0.77)	0.001
Absence of tenderness but synovitis
Not tender+clinical synovitis	No	1524	125 (8.7%)	1.32 (0.93 to 1.87)	0.116
Not tender+clinical synovitis	Yes	362	34 (9.9%)	1.32 (0.93 to 1.87)	0.116
Not tender+B-mode synovitis	No	1338	103 (8%)	1.21 (0.88 to 1.66)	0.241
Not tender+B-mode synovitis	Yes	545	56 (11.3%)	1.21 (0.88 to 1.66)	0.241
Not tender+PDUS synovitis	No	1659	129 (8.3%)	1.31 (0.89 to 1.91)	0.168
Not tender+PDUS synovitis	Yes	224	30 (13.9%)	1.31 (0.89 to 1.91)	0.168

PDUS, power Doppler ultrasound.