Intergenic RA-associated regions that overlap lincRNA
| RA-associated region | Lead SNP | Gene | Expl.H2 | OR | Overlapping lincRNA |
|---|---|---|---|---|---|
| chr1:38614865–38644861 | rs12140275 | POU3F1 | 0.039 | 1.11 | lnc-UTP11L-2 |
| chr2:100806512–100835734 | rs9653442 | AFF3 | 0.064 | 1.11 | lnc-NMS-1 |
| chr4:26085478–26128710 | rs11933540 | SMIM20 | 0.101 | 1.15 | lnc-RBPJ-1 |
| chr6:137959233–138006504 | rs17264332 | TNFAIP3 | 0.100 | 1.17 | lnc-OLIG3-1 and lnc-TNFAIP3-3 |
| chr6:159489789–159515309 | rs2451258 | TAGAP | 0.041 | 1.10 | lnc-FNDC1-7 |
| chr8:102451261–102469182 | rs678347 | GRHL2 | 0.034 | 1.08 | lnc-ZNF706-5 |
| chr8:129540462–129571140 | rs1516971 | TMEM75 | 0.044 | 1.15 | lncTMEM75-2 |
| chr15:69984460–70010647 | rs8026898 | RPLP1 | 0.079 | 1.15 | lnc-RPLP1-2 |
| chr16:86005836–86021627 | rs13330176 | IRF8 | 0.064 | 1.12 | lnc-IRF8-5 |
Included is the associated region (r2=0.8), lead SNP, closest protein-coding gene (Gene), explained heritability (Expl.H2, %) OR and overlapping lincRNA (LNCipedia nomenclature).19 Explained heritability and ORs are taken from Okada et al.5
RA, rheumatoid arthritis; SNP, single nucleotide polymorphism.