Comparison of the association of HLA-DRB1 alleles and structural progression according to the classification of HLA-DRB1 alleles on ESPOIR and EAC cohorts
| ESPOIR | EAC | Meta-analysis | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Acid–base | ||||||
| BB | 3.05 (2.03 to 4.57) | <0.001 | 1.78 (1.19 to 2.66) | 0.005 | 2.33 (1.76 to 3.09) | <0.001 |
| BN | 0.94 (0.64 to 1.38) | 0.76 | 1.10 (0.74 to 1.63) | 0.65 | 1.01 (0.77 to 1.33) | 0.92 |
| A | 0.35 (0.21 to 0.59) | <0.001 | 0.32 (0.17 to 0.58) | <0.001 | 0.34 (0.23 to 0.50) | <0.001 |
| NN and X | 0.65 (0.43 to 0.96) | 0.03 | 0.79 (0.52 to 1.19) | 0.25 | 0.71 (0.53 to 0.94) | 0.018 |
| De Vries | ||||||
| SE | 3.73 (2.39 to 5.91) | <0.001 | 2.26 (1.49 to 3.44) | <0.001 | 2.91 (2.16 to 3.92) | <0.001 |
| N | 0.60 (0.41 to 0.87) | 0.008 | 0.67 (0.45 to 0.99) | 0.04 | 0.63 (0.48 to 0.83) | <0.001 |
| P | 0.55 (0.38 to 0.81) | 0.002 | 0.61 (0.41 to 0.91) | 0.02 | 0.58 (0.44 to 0.76) | <0.001 |
| Mattey | ||||||
| SE | 3.73 (2.39 to 5.91) | <0.001 | 2.26 (1.49 to 3.44) | <0.001 | 2.91 (2.16 to 3.92) | <0.001 |
| D70− | 0.88 (0.60 to 1.29) | 0.5 | 0.65 (0.43 to 0.96) | 0.03 | 0.76 (0.58 to 1.00) | 0.05 |
| D70+ | 0.44 (0.29 to 0.66) | <0.001 | 0.77 (0.52 to 1.15) | 0.2 | 0.58 (0.44 to 0.77) | <0.001 |
| Du Montcel | ||||||
| S1 | 0.53 (0.34 to 0.82) | <0.001 | 0.47 (0.31 to 0.70) | <0.001 | 0.50 (0.34 to 0.67) | <0.001 |
| S2 | 1.26 (0.85 to 1.86) | 0.2 | 1.65 (1.10 to 2.49) | 0.02 | 1.43 (1.08 to 1.90) | 0.01 |
| S3D | 0.40 (0.24 to 0.66) | <0.001 | 1.19 (0.71 to 2.00) | 0.5 | 0.65 (0.46 to 0.92) | 0.02 |
| S3P | 2.18 (1.49 to 3.21) | <0.001 | 2.18 (1.45 to 3.29) | <0.001 | 2.18 (1.65 to 3.21) | <0.001 |
| X | 0.78 (0.52 to 1.16) | 0.2 | 0.79 (0.53 to 1.16) | 0.2 | 0.78 (0.60 to 1.03) | 0.08 |
| Reviron | ||||||
| SE | 3.73 (2.39 to 5.91) | <0.001 | 2.26 (1.49 to 3.44) | <0.001 | 2.91 (2.16 to 3.92) | <0.001 |
| XP4P | 0.89 (0.61 to 1.30) | 0.5 | 0.68 (0.46 to 1.02) | 0.5 | 0.78 (0.60 to 1.03) | 0.08 |
| XP4N | 0.51 (0.35 to 0.76) | <0.001 | 0.77 (0.52 to 1.14) | 0.5 | 0.63 (0.48 to 0.82) | <0.001 |
95% CI.
BB, allele group containing basic AA at positions 13, 70 and 71; BN, allele group containing either a basic amino acid at position 13 and a neutral or acid and basic amino acid at positions 70 and 71 or a neutral amino acid at position 13 and a basic amino acid at positions 70 and 71; A, allele group containing acid amino acids at positions 70 and 71; NN, allele group with a neutral amino acid at position 13 and either a basic and an acidic amino acid at positions 70 and 71 or two neutral amino acids at positions 70 and 71; X, allele group not containing RAA sequence at positions 72–74; N, allele group not containing an isoleucine at position 67; P, allele group containing an isoleucine at position 67; SE, shared epitope; D70−, allele group not containing an aspartic acid at position 70; D70+, allele group containing an aspartic acid at position 70; XP4p, fourth pocket positively charged; XP4n, fourth pocket negatively or non-charged.