Univariable and multivariable logistic regression analysis with SHS progression as binomial outcome variable
| OR | 95% CI | p Value | |
|---|---|---|---|
| Univariable analysis | |||
| Age | 1.03 | 1.01 to 1.06 | 0.009 |
| Female | 0.89 | 0.48 to 1.66 | 0.720 |
| RA | 1.12 | 0.52 to 2.39 | 0.777 |
| DAS | 1.08 | 0.79 to 1.48 | 0.648 |
| Symptom duration <12 weeks | 0.55 | 0.28 to 1.11 | 0.096 |
| RF | 1.46 | 0.77 to 2.75 | 0.244 |
| Anti-CarP/ACPA | |||
| Both negative | ref | ||
| Anti-CarP−ACPA+ | 1.27 | 0.53 to 3.05 | 0.592 |
| Anti-CarP+ACPA−* | 0.86 | 0.10 to 7.04 | 0.885 |
| Both positive | 2.67 | 1.26 to 5.66 | 0.011 |
| CRP | 1.00 | 0.99 to 1.01 | 0.646 |
| ESR >28 mm | 2.27 | 1.25 to 4.15 | 0.007 |
| SJC | 1.02 | 0.98 to 1.07 | 0.338 |
| TJC | 0.99 | 0.93 to 1.05 | 0.661 |
| DAS remission 4 months | 0.97 | 0.53 to 1.79 | 0.932 |
| Arm 1† | 1.80 | 0.57 to 5.69 | 0.317 |
| Arm 2‡ | 0.56 | 0.18 to 1.76 | 0.317 |
| Early ACR/EULAR remission | 1.44 | 0.76 to 2.74 | 0.266 |
| SHS | 1.10 | 1.00 to 1.20 | 0.041 |
| Erosion score | 1.00 | 1.00 to 1.02 | 0.812 |
| JSN score | 1.00 | 1.00 to 1.00 | 0.804 |
| Early DXR-BMD loss | 1.22 | 1.03 to 1.45 | 0.019 |
| Early DXR-BMC loss, imputed§ | 1.18 | 0.97 to 1.45 | 0.100 |
| Multivariable analysis | |||
| Age | 1.03 | 1.00 to 1.06 | 0.049 |
| Anti-CarP/ACPA | |||
| Both negative | ref | ||
| Anti-CarP−ACPA + | 1.41 | 0.57 to 3.46 | 0.457 |
| Anti-CarP+ACPA−* | 1.13 | 0.13 to 9.68 | 0.908 |
| Both positive | 2.54 | 1.16 to 5.58 | 0.020 |
| Symptom duration <12 weeks | 0.49 | 0.23 to 1.04 | 0.063 |
| ESR >28 mm | 1.90 | 0.95 to 3.81 | 0.070 |
| SHS | 1.04 | 0.98 to 1.11 | 0.208 |
*n=16 patients.
†Reference category arm 2.
‡Reference category arm 1.
§DXR-BMD data imputed in 442 patients.
ACPA, anticitrullinated protein antibodies; Anti-CarP, anticarbamylated protein antibodies; ACR, American College of Rheumatology; CRP, C reactive protein; DAS, disease activity score; DXR-BMD, metacarpal bone mineral density measured by digital X-ray radiogrammetry; ESR, erythrocyte sedimentation rate; EULAR, European League Against Rheumatism; JSN, joint space narrowing; RA, rheumatoid arthritis; RF, rheumatoid factor; SHS, Sharp/van der Heijde score; SJC, swollen joint count; TJC, tender joint count; Wks, weeks.