Table 2

Clinical summary for pSS fatigue groups showing mean±SD for key demographics, haematological and clinical variables

VariableMinimalMildModerateSeverep Value
Age (years)62±1058±1460±1259±13ns
Disease duration (years)5.5±5.86.1±5.27.5±6.29.1±7.3ns
Symptom duration (years)13±1013±1114±1116±13ns
BMI (kg/m2)25±4.426±4.226±6.328±7.2ns
% Anti-Ro/La positive91.6795.4583.0892.31ns
% Not taking any immune-altering medications67595250ns
% On hydroxychloroquine17343734ns
% On prednisolone85612ns
% On ‘other’ immune-altering medications8254ns
ESSDAI5.4±5.77.6±8.25.9±5.27.2±6.1ns
ESSPRI2.9±1.34.3±1.46.6±1.48.3±1.1≤0.0001
ESSPRI pain1.4±1.53.2±2.55.4±2.68±1.6≤0.0001
ESSPRI dryness5.6±2.75.5±2.26.9±2.68.1±2≤0.0001
EULAR SS5.3±2.55.6±2.56.8±2.57.8±20.0004
HADS anxiety (0–21)3.7±2.46.5±3.58.6±4.412±4.9≤0.0001
HADS depression (0–21)2±1.94±2.87.4±3.511±2.9≤0.0001
Hb (g/dL)12±1.613±1.213±1.213±1.1ns
WCC (×109/L)5.5±1.45.2±1.55.2±2.06.3±2.7ns
Neutrophil (×109/L)3.5±1.13.3±1.33.2±1.53.7±2ns
Lymphocyte (×109/L)1.4±0.61.3±0.51.4±0.61.9±0.90.002
ESR (mm/h)39±2633±2527±2424±20ns
CRP (mg/L)6.4±55±4.15.2±5.96.7±5.8ns
IgG (mg/dL)20±8.818±815±6.515±4.20.008
  • BMI, body mass index; CRP, C-reactive protein; ESSDAI, EULAR Sjögren's Syndrome Disease Activity Index; ESR, erythrocyte sedimentation rate; ESSPRI, EULAR Sjögren's Syndrome Patient Reported Index; EULAR SS, EULAR Sicca Score; HADS, Hospital Anxiety and Depression Score; Hb, haemoglobin; pSS, primary Sjögren's syndrome; WCC, white cell count.