Results of the meta-analysis on the three cohorts assessing the association of a SNP on RANK, a haplotype on RANKL with ACPA; and a SNP on RANKL, a SNP on OPG with erosions
| ESPOIR | FRAGC | RMP | Meta-analysis | ||
|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | p Value | |
| Association with ACPA | |||||
| RANK C allele of rs8086340 | 0.64 (0.45 to 0.91) | 0.71 (0.47 to 1.06) | 0.46 (0.23 to 0.92) | 0.64 (0.50 to 0.81) | 0.0003 |
| RANKL GGG Haplotype | 0.58 (0.38 to 0.89) | 0.60 (0.34 to 1.03) | 0.93 (0.43 to 1.98) | 0.63 (0.46 to 0.86) | 0.003 |
| Association with erosions | |||||
| RANKL G allele of rs7325635 | 1.75 (1.18 to 2.82) | 0.67 (0.39 to 1.16) | 0.50 (0.26 to 0.98) | 0.97 (0.71 to 1.32) | 0.85 |
| OPG G allele of rs2073618 | 0.72 (0.49 to 1.04) | 0.49 (0.31 to 0.78) | 1.10 (0.59 to 2.05) | 0.68 (0.52 to 0.88) | 0.004 |
ACPA, anticitrullinated peptide antibodies; RANK, receptor activator of nuclear factor κ B; RANKL, receptor activator of nuclear factor κ B ligand; OPG, osteoprotegerin; SNP, single-nucleotide polymorphisms.