Week 4 | Week 8 | Week 12 | Week 24 | Week 36 | Week 52 | Week 76 | |
---|---|---|---|---|---|---|---|
MTX-PG1 | 0.018 (0.011) p=0.11 | −0.003 (0.008) p=0.68 | −0.025 (0.007)* p=0.000 | −0.026 (0.009)* p=0.005 | −0.013 (0.010) p=0.022 | −0.008 (0.015) p=0.59 | 0.009 (0.013) p=0.49 |
MTX-PG2 | 0.018 (0.016) p=0.27 | −0.002 (0.013) p=0.86 | −0.035 (0.011)* p=0.002 | −0.027 (0.012)* p=0.03 | −0.023 (0.016) p=0.15 | −0.013 (0.017) p=0.45 | 0.021 (0.022) p=0.35 |
MTX-PG3 | 0.019 (0.026) p=0.48 | −0.035 (0.017)* p=0.04 | −0.023 (0.013) p=0.07 | −0.028 (0.014)* p=0.04 | −0.030 (0.015)* p=0.04 | −0.006 (0.020) p=0.76 | 0.005 (0.022) p=0.83 |
Total MTX-PG | 0.008 (0.006) p=0.19 | −0.003 (0.005) p=0.41 | −0.013 (0.004)* p=0.003 | −0.014 (0.004)* p=0.003 | −0.009 (0.005) p=0.09 | −0.005 (0.007) p=0.43 | 0.006 (0.007) p=0.41 |
Upper: β, SE.
Lower: p.
*p<0.05.
DAS28, Disease Activity Score for 28 joints; MTX-PG, methotrexate polyglutamate.