DAS28-CRP estimation* | Sensitivity+specificity (maximum) | Concordance (maximum) | DAS28-CRP cut-offs†, mean (SD) | |
---|---|---|---|---|
COMET | ||||
ETN+MTX | 4.52 | 4.78 | 4.55 | 4.62 (0.14) |
MTX | 4.55 | 4.92 | 4.55 | 4.68 (0.21) |
PRIZE | ||||
ETN+MTX | 4.51 | 5.01 | 4.34 | 4.62 (0.35) |
Pooled | ||||
All | 4.64 (0.03) |
*Based on DAS28-CRP and DAS28-ESR cumulative distribution plots.
†Based on mean of all three statistical approaches, presented per treatment group.
DAS28-CRP, Disease Activity Score in 28 joints calculated with C reactive protein; DAS28-ESR, Disease Activity Score in 28 joints calculated with erythrocyte sedimentation rate; ETN, etanercept; HDA, high disease activity; MTX, methotrexate.