Table 2

DAS28-CRP HDA cut-off estimation that corresponds to DAS28-ESR>5.1

DAS28-CRP estimation*Sensitivity+specificity (maximum)Concordance (maximum)DAS28-CRP cut-offs†, mean (SD)
COMET
ETN+MTX4.524.784.554.62 (0.14)
MTX4.554.924.554.68 (0.21)
PRIZE
ETN+MTX4.515.014.344.62 (0.35)
Pooled
All4.64 (0.03)
  • *Based on DAS28-CRP and DAS28-ESR cumulative distribution plots.

  • †Based on mean of all three statistical approaches, presented per treatment group.

  • DAS28-CRP, Disease Activity Score in 28 joints calculated with C reactive protein; DAS28-ESR, Disease Activity Score in 28 joints calculated with erythrocyte sedimentation rate; ETN, etanercept; HDA, high disease activity; MTX, methotrexate.