Patient’s characteristics
| Patient 1 | Patient 2 | Patient 3 | |
| Age at the beginning of the treatment | 39 years | 52 years | 35 years |
| Genre | Female | Female | Male |
| Medical history | Osteoporosis | Type 2 diabetes Overlap syndrome Bipolar disorder Osteoporosis Hypothyroidism | |
| Duration of illness until TCZ | 10 years | 8 years | 3 months |
| Organs concerned | Muscle Aneurysms kidney arteries | Muscle Neuropathy Skin and soft tissue Occlusion and aneurysm of arm arteries | Muscle Neuropathy |
| ACR diagnostic criteria | Weight loss >4 kg Myalgias Diastolic pressure >90 mm Hg creatinine >1.5 mg/dL Biopsy of small-sized or medium-sized artery containing PNN aneurysms or occlusions of the visceral arteries | Weight loss >4 kg Livedo reticularis Myalgias, polyneuropathy Biopsy of small-sized or medium-sized artery containing PNN aneurysms or occlusions of the visceral arteries | Weight loss >4 kg Myalgias, polyneuropathy Biopsy of small-sized or medium-sized artery containing PNN |
| Previous immunosuppressive therapeutics | Corticosteroids Methotrexate Mycophenolate mofetil Cyclophosphamide intravenous Infliximab | Corticosteroids Dapsone Methotrexate Cyclophosphamide intravenous Oral cyclophosphamide Azathioprine | Corticosteroids |
ACR, American College of Rheumatology; PNN, polynuclear neutrophils; TCZ, tocilizumab.