Table 3

HR of death in patients with AAV across subgroups identified by cluster affiliation, multivariable Cox regression

HRLCL HRUCL HRp Value
Female1(reference)
Male (0–1.85 years)1.890.923.900.084
Male (1.85–8.5 years)0.840.461.550.582
Male (>8.5 years)0.340.130.900.029
Age (1-year increase)1.091.071.12<0.001
Cluster A, non-renal1(reference)
Cluster B, renal with PR32.531.255.120.010
Cluster C, renal without PR32.701.345.460.005
Cluster D, cardiovascular6.382.5216.15<0.001
Cluster E, gastrointestinal3.981.5210.390.005
  • Cluster affiliation for AAV (Mahr et al 8) with nine clinical variables and ANCA specificity.

  • AAV, ANCA-associated vasculitis; ANCA, antineutrophil cytoplasmatic antibody; LCL, lower confidence limit; PR3 proteinase 3; UCL; upper confidence limit.