ORs with 95% CIs of developing rheumatoid arthritis (RA) for subjects who have been exposed to permanent night shift work, rotating shift work, or day oriented shift work, compared with those who have never been exposed
| ACPA-positive | RA | ACPA-negative RA | ||||
| Type of shift work | ca/co* (n, %) | OR (95% CI)† | p Value | ca/co* (n, %) | OR (95% CI)† | p Value |
| Never | 828 (67)/1537 (69) | 1.0 (reference) | 514 (71)/1537 (69) | 1.0 (reference) | ||
| Day oriented shift work | 144 (12)/244 (11) | 1.3 (1.0 to 1.7) | 0.04 | 67 (9)/244 (11) | 1.0 (0.7 to 1.4) | 0.9 |
| Rotating shift work | 163 (13)/252 (11) | 1.3 (1.0 to 1.6) | 0.03 | 84 (12)/252 (11) | 1.1 (0.9 to 1.5) | 0.4 |
| Permanent night shift work | 97 (8)/192 (9) | 0.7 (0.6 to 0.9) | 0.005 | 54 (8)/192 (9) | 0.8 (0.6 to 1.0) | 0.03 |
*Exposed cases and controls
†Adjusted for age, gender, residential area, ancestry, and smoking.
ACPA, anticitrullinated peptide antibodies.