Cox regression analysis for time to first hospitalised cardiovascular event after rheumatoid arthritis diagnosis
| Unadjusted, HR (95% CI) | Age-adjusted and sex-adjusted, HR (95% CI) | Fully adjusted*, HR (95% CI) | |
| Smoking status | |||
| Current vs never | 1.64 (1.1 to 2.44) | 2.19 (1.44 to 3.31) | 2.23 (1.46 to 3.40) |
| Current vs former | 0.81 (0.57 to 1.15) | 1.35 (0.94 to 1.93) | 1.51 (1.04 to 2.19) |
| Former vs never | 2.02 (1.44 to 2.83) | 1.62 (1.15 to 2.29) | 1.47 (1.04 to 2.08) |
| Smoking cessation | |||
| Per year since cessation, light smoker | 0.80 (0.69 to 0.92) | 0.76 (0.66 to 0.88) | 0.77 (0.66 to 0.91) |
| Per year since cessation, heavy smoker | 0.78 (0.67 to 0.91) | 0.74 (0.63 to 0.86) | 0.73 (0.62 to 0.87) |
| Heavy vs light smoker† | 1.31 (0.65 to 2.65) | 1.68 (0.82 to 3.45) | 1.80 (0.79 to 4.10) |
| Interaction‡ | 0.98 (0.84 to 1.13) | 0.97 (0.83 to 1.12) | 0.95 (0.80 to 1.12) |
HR, hazard ratio; CI, confidence interval
*Adjusted for gender, age, Townsend score, use of immunosuppressant disease-modifying antirheumatic drugs, use of oral glucocorticoids, use of non-steroidal anti-inflammatory drugs, type2 diabetes, use of cardiovascular drugs, use of aspirin/antiplatelet drugs, use of lipid regulators and body mass index.
†At the time of cessation.
‡Interaction between years of cessation and amount smoked.