Table 1

Haplotype analysis based on the UK subset described in the International Genetics of Ankylosing Spondylitis Consortium Immunochip study showing the presence of four distinct RUNX3 haplotypes including rs4265380 and rs4648889. The CA haplotype has the highest risk for ankylosing spondylitis relative to the common reference CG haplotype

rs4265380
rs4648889
Counts in casesCounts in controlsFrequency in casesFrequency in controlsP valueOR
CG388295900.460.49
TA447795890.530.495.7×10–81.15 (1.1–1.2)
TG5316×10–40.0026.3×10–20.4 (0.12–1.03)
CA30120.0046×10–41.4×10–86.2 (3.1–13.2)