Changes in cardiovascular risk factors in patients with PsA and matched controls (values obtained from the mixed linear model)
| PsA (n=151) | Matched controls (n=755) | Difference in mean change between groups (95% CI) | P crude | P value | |||||
| HUNT2 (1995–1997) | HUNT3 (2006–2008) | Mean change | HUNT2 (1995–1997) | HUNT3 (2006–2008) | Mean change | ||||
| Weight, kg | 80.4 (78.2 to 82.7) | 82.5 (80.2 to 84.7) | 2.06 (0.90 to 3.22) | 75.9 (74.5 to 77.3) | 79.8 (78.4 to 81.2) | 3.88 (3.36 to 4.40) | −1.82 (−3.98 to −0.55) | <0.01 | NA |
| BMI, kg/m2 | 27.3 (26.6 to 27.9) | 28.2 (27.6 to 28.9) | 0.97 (0.57 to 1.37) | 25.9 (25.6 to 26.3) | 27.5 (25.2 to 27.8) | 1.53 (1.35 to 1.70) | −0.65 (−1.00 to −0.12) | 0.01 | NA |
| Triglycerides | 1.87 (1.70 to 2.04) | 1.80 (1.62 to 1.97) | −0.07 (−0.25 to 0.11) | 1.69 (1.60 to 1.77) | 1.69 (1.60 to 1.77) | 0.00 (−0.08 to 0.08) | −0.07 (−0.27 to 0.12) | 0.46 | 0.99* |
| Total cholesterol | 5.85 (5.68 to 6.03) | 5.57 (5.39 to 5.74) | −0.29 (−0.48 to −0.10) | 5.78 (5.69 to 5.90) | 5.71 (5.62 to 5.81) | −0.06 (−0.15 to 0.02) | −0.22 (−0.43 to −0.02) | 0.04 | 0.08* |
| LDL cholesterol | 4.82 (4.66 to 4.10) | 3.44 (3.28 to 3.60) | −1.39 (−1.56 to −1.21) | 4.81 (4.73 to 4.89) | 3.60 (3.52 to 3.70) | −1.2 (−1.28 to −1.13) | −0.18 (−0.38 to 0.01) | 0.06 | 0.11* |
| HDL cholesterol | 1.32 (1.26 to 1.37) | 1.32 (1.26 to 1.38) | 0.00 (−0.04 to 0.05) | 1.39 (1.36 to 1.42) | 1.36 (1.33 to 1.39) | −0.03 (−0.05 to −0.02) | 0.04 (−0.01 to 0.09) | 0.13 | 0.45* |
| Systolic blood pressure | 132.8 (129.9 to 135.6) | 132.1 (129.1 to 135.1) | −0.65 (−3.63 to 2.32) | 131.5 (129.9 to 133.1) | 131.6 (129.9 to 133.2) | 0.02 (−1.31 to 1.35) | −0.67 (−3.93 to 2.59) | 0.69 | 0.98† |
| Diastolic blood pressure | 79.9 (78.2 to 81.6) | 75.5 (73.7 to 77.3) | −4.42 (−9.22 to −2.62) | 79.1 (78.1 to 79.9) | 75.1 (74. 1 to 76.1) | −3.96 (−4.76 to −3.15) | −0.46 (−2.43 to 1.52) | 0.65 | 0.90† |
Values are mean (95% CI). Difference in mean change between groups with 95% CI is calculated with mixed models as mean of the patients with PsA minus mean of the matched controls.
*Adjusted for BMI and smoke at baseline.
†Adjusted for BMI, smoke and use of antihypertensive medication at baseline.
BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NA, not applicable; PsA, psoriatic arthritis.