Abstract
With the aid of monoclonal antibodies, macrophages can be split into functionally distinct subpopulations on the basis of their phenotype. Absence of macrophage subtypes has been noted in chronic inflammatory processes, e.g. posttraumatic osteomyelitis, rheumatoid arthritis and sarcoidosis. In the inflammatory focus of acute septic arthritis (n = 13 patients) however, macrophages constitute the majority of immunocompetent cells. The inflammatory macrophage subtype 27E10 was clearly present in increased numbers in 11 of 13 biopsies from the inflammatory foci, showing the effector task of this subtype in synovial resistance. The anti-inflammatory macrophage subset RM3/1 was present in increased numbers in biopsies of infected tissue and the surrounding soft tissue. The occurrence of 25F9-positive macrophages, typical of the late phase of inflammation, varied widely in the biopsies.
Similar content being viewed by others
References
Bhardwaj RS, Zotz C, Zwadlo-Klarwasser G, Roth J, Goebeler M, Mahnke K, Meinardus-Hager G, Sorg C (1992) The calcium-binding proteins MRP 8 and MRP 14 from a membrane-associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions. Eur J Immunol 22:1891–1897
Goldberg DL, Reed JI (1985) Bacterial arthritis. N Engl J Med 312:764–771
Horwitz MA, Levis WR, Cohn ZA (1984) Defective production of monocyte activating lymphokines in lepromatous leprosy. J Exp Med 159:666–678
Kleesiek K (1987) Blutzellen und blutbildende Organe. In: Greiling H, Gressner AM (eds) Lehrbuch der Klinischen Chemie und Pathobiochemie. Schattauer, Stuttgart, pp 692–693
Morahan PS, Volkmann A, Melnicoff M, Dempsey WL (1988) Macrophage heterogeneity. In: Heppner GH, Fultan A (eds) Macrophage and cancer. CRC Press, Boca Raton, pp 1–35
Nathan CF (1987) Secretory products of macrophages. J Clin Invest 79:319–326
Oestern HJ (1988) Radikalität und strukturgerechte Versorgung. In: Kramer G (ed) Weichteilschäden, Diagnostik und Therapie. VCH, Weinheim, pp 97–106
Peters KM, Zwadlo-Klarwasser G, Koberg K, Rosendahl T, Zilkens KW, Schmutzler W (1993) Suppression of macrophage subsets in posttraumatic osteomyelitis. Z Orthop 131:37–41
Radzun HJ, Kreipe H, Barth J, Parawesch MR (1989) Phäno-typische Analyse und Genexpression entzündlicher Reaktionsformen des Monozyten/Makrophagensystems. Immun Infekt 17:175–180
Seymour GJ, Gemmel E, Walsch LJ, Powell RN (1988) Immunohistological analysis of experimental gingivitis in humans. Clin Exp Immunol 71:132–137
Topoll HH, Zwadlo G, Lange DE, Sorg C (1989) Phenotypic dynamics of macrophage subpopulation during human experimental gingivitis. J Periodont Res 24:106–112
Zwadlo G, Bröcker EB, Bassewitz DB, Feige U, Sorg C (1985) A monoclonal antibody to a differentiation antigen on mature human macrophages and absent from monocytes. J Immunol 134:1487–1492
Zwadlo G, Schlegel R, Sorg C (1986) A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues. J Immunol 137:512–519
Zwadlo G, Voegeli R, Osthoff KS, Sorg C (1987) A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process. Exp Cell Biol 56:295–304
Zwadlo-Klarwasser G, Bent S, Haubeck HD, Sorg C, Schmutzler W (1990) Glucocorticoid-induced appearance on the macrophage subtype RM 3/1 in the peripheral blood of man. Int Arch Allergy Appl Immunol 91:175–180
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peters, K.M., Koberg, K., Rosendahl, T. et al. Macrophage reactions in septic arthritis. Arch Orthop Trauma Surg 115, 347–350 (1996). https://doi.org/10.1007/BF00420330
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00420330