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Role of IL-1b and TNF-a in the regulation of NGF in experimentally induced arthritis in mice

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Abstract

The aim of this study was to investigate the effects of IL-1β and TNF-α on NGF levels in the knee joint in experimentally induced arthritis in adult mice. Out data showed that IL-1β, but not TNF-α, induces an increase in NGF levels, while concomitant injection of both cytokines enhances the effect of IL-1β on NGF presence. Analysis of NGF levels in the knee joint of carrageenan- and IL-1β-induced inflammation after administration of antibodies against TNF-α supports this hypothesis. Our studies also showed that exogenous administration of NGF antibody reduces the enhanced level of TNF-α occurring in arthritic mice. This latter observation indirectly suggests that NGF is implicated in the upregulation of TNF-α in these animal models of joint inflammation. The functional significance of NGF or NGF antibody in inflammatory arthritis is discussed.

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Received: 16 March 1998 / Accepted: 2 July 1998

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Manni, L., Aloe, L. Role of IL-1b and TNF-a in the regulation of NGF in experimentally induced arthritis in mice. Rheumatology International 18, 97–102 (1998). https://doi.org/10.1007/s002960050065

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  • DOI: https://doi.org/10.1007/s002960050065

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