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Impact of smoking and quitting on cardiovascular outcomes and risk advancement periods among older adults

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Abstract

Smoking is an established risk factor for cardiovascular events, such as myocardial infarction, stroke and cardiovascular death. However, most pertinent studies primarily relied on middle aged adults. We aimed to provide empirical evidence on the association of smoking with cardiovascular events and the benefits of smoking cessation in people aged 50 years or older. In a German population-based cohort study detailed information on lifetime smoking history was obtained from 8,807 individuals aged 50–74 years, without previous myocardial infarction (MI) or stroke. Cox proportional hazards regression was applied to estimate the impact of smoking on MI, stroke and cardiovascular death (CVD) as well as on the combined outcome of major cardiovascular events (MI, stroke or CVD). In addition, the impact of smoking and the benefits of smoking cessation were quantified by risk advancement periods (RAP). The cohort included 17.2 % current smokers, 31.7 % former smokers and 51.1 % never smokers. During a mean follow-up of 9.1 years, 261 participants experienced a first MI, 456 had a primary stroke and 274 died of cardiovascular reasons. Compared to never smokers, adjusted hazard ratios (95 % confidence intervals) of current smokers were 2.25 (1.62–3.12), 2.12 (1.65–2.73) and 2.45 (1.76–3.42) and RAPs were 19.3, 9.8 and 8.4 years for MI, stroke and CVD, respectively. Strong dose–response relationships were seen with both current and life-time amount of smoking. Most of the excess risk and risk advancement disappeared within 5 years after smoking cessation. Smoking is a strong risk factor for cardiovascular events even at older age. Smoking cessation is highly and rapidly beneficial also at advanced age.

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Acknowledgments

The ESTHER study was funded by the Baden-Württemberg state Ministry of Science, Research and Arts (Stuttgart, Germany), the Federal Ministry of Education and Research (Berlin, Germany) and the Federal Ministry of Family Affairs, Senior Citizens, Women and Youth (Berlin, Germany). This analysis was conducted in the context of the CHANCES project funded in the FP7 framework programme of DG-RESEARCH in the European Commission. The project is coordinated by the Hellenic Health Foundation, Greece.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

    Carolin Gellert, Ben Schöttker, Heiko Müller & Hermann Brenner

  2. Saarland Cancer Registry, Präsident-Baltz-Straße 5, 66119, Saarbrücken, Germany

    Bernd Holleczek

  3. Division of Clinical Epidemiology and Aging Research (C070), German Cancer Research Center (DKFZ), PO Box 101949, 69009, Heidelberg, Germany

    Hermann Brenner

Authors
  1. Carolin Gellert
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  2. Ben Schöttker
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  3. Heiko Müller
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  4. Bernd Holleczek
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  5. Hermann Brenner
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Correspondence to Hermann Brenner.

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Gellert, C., Schöttker, B., Müller, H. et al. Impact of smoking and quitting on cardiovascular outcomes and risk advancement periods among older adults. Eur J Epidemiol 28, 649–658 (2013). https://doi.org/10.1007/s10654-013-9776-0

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  • DOI: https://doi.org/10.1007/s10654-013-9776-0

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