Elsevier

Immunology Today

Volume 11, 1990, Pages 443-449
Immunology Today

Review
Biological and clinical aspects of interleukin 6

https://doi.org/10.1016/0167-5699(90)90173-7Get rights and content

Abstract

Interleukin 6(IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.

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