Elsevier

Joint Bone Spine

Volume 74, Issue 3, May 2007, Pages 304-305
Joint Bone Spine

Letter to the editor
Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis

https://doi.org/10.1016/j.jbspin.2006.11.005Get rights and content

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Methods

We included patients who met modified New York criteria for AS and who were not receiving immunomodulating drugs or drugs known to affect bone metabolism. Age- and sex-matched controls were selected among untreated individuals who had no inflammatory or bone disease.

The following data were collected in each patient: disease duration, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Global score

Results

We included 28 patients with AS (22 men and 6 women), whose mean age was 42 years and mean disease duration 14 years. Mean values of disease-related variables were as follows: BASDAI, 42.0 mm; BASFI, 35.5 mm; BAS-G, 49.6 mm; ESR, 32.7 mm; CRP, 21.7 mg/L; and IgA, 2.79 g/L. Table 1 lists the main results. Serum IL-17 levels were significantly higher in the patients than the controls. No distinctive features were identified in the patients with the highest IL-17 levels. Non-significant serum BMP-7

Discussion

In a group of patients with established AS and evidence of active inflammation (ESR  30 mm, CRP  20 mg/L, and BASDAI  40), the bone formation marker BALP was decreased and the bone resorption marker TRAP was increased compared to controls. In the patients, sCTX correlated with ESR. These findings are consistent with earlier data and with the occurrence of bone loss in some AS patients [1], [2].

Serum IL-17 levels were significantly higher in AS patients than in controls. They failed to correlate with

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