Elsevier

Joint Bone Spine

Volume 78, Issue 4, July 2011, Pages 422-423
Joint Bone Spine

Letter to the editor
Serum Dkk-1 levels of DISH patients are not different from healthy controls

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The authors declare that they have no conflicts of interest concerning this article.

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    The authors suggested that Dkk-1 may play a significant role in the process of new bone formation in DISH. These findings were challenged by a recent cross-sectional study that showed no difference in functional Dkk-1 levels in patients with DISH compared with healthy controls [33]. Therefore, the role of Dkk-1 in the pathogenesis of DISH remains questionable.

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  • Pathogenesis of hyperostosis: A key role for mesenchymatous cells?

    2013, Joint Bone Spine
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    In addition, the lowest DKK-1 levels were associated with the greatest severity of spinal hyperostosis independently from age, sex, bone turnover markers, and bone mineral density [21]. However, another study failed to replicate this finding [22]. Rather than osteoblast dysfunction, abnormal differentiation of osteoblast precursors, most notably mesenchymous stem cells, may be central to the pathogenesis of DISH according to several recent studies (see below).

  • Diffuse idiopathic skeletal hyperostosis (Forestier-Rotes-Querol disease): What's new?

    2013, Joint Bone Spine
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    Serum DKK-1 levels were significantly decreased in 37 patients with DISH (meeting Resnick's definition), and the lowest levels were seen in the patients who had the most extensive ossifications [26]. Another study, however, found no decrease in serum DKK-1 levels in 27 patients with DISH compared to 26 healthy controls [27]. The issue is therefore unresolved.

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