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Polymer therapeutics

Reservoir drugs

Peptide-functionalized polymer nanoparticles target and bind to articular cartilage tissue, making them promising drug-delivery vehicles.

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Figure 1: The composition of a synovial joint and articular cartilage.
Figure 2: A schematic representation of the peptide–polymer nanoparticle.

References

  1. Connelly, L. B. Woolf, A. & Brooks, P. Disease Control Priorities in Developing Countries 2nd edn, 963–980 (Oxford Univ. Press, New York, 2006).

    Google Scholar 

  2. Woolf, A. D. & Pfleger, B. Bull. World Health Organ. 81, 646–656 (2003).

    Google Scholar 

  3. Rothenfluh, D. A., Bermudez, H., O'Neil, C. P. & Hubbell, J. A. Nature Mater. 7, 248–254 (2008).

    Article  CAS  Google Scholar 

  4. Maroudas, A. Biorheology 12, 233–248 (1975).

    Article  CAS  Google Scholar 

  5. Levick, J. R. Arthritis Rheum. 24, 1550–1560 (1981).

    Article  CAS  Google Scholar 

  6. Gerwin, N., Hops, C. & Lucke, A. Adv. Drug Deliv. Rev. 58, 226–242 (2006).

    Article  CAS  Google Scholar 

  7. Evans, C. H., Ghivizzani, S. C. & Robbins, P. D. Arthritis Rheum. 54, 1714–1729 (2006).

    Article  CAS  Google Scholar 

  8. Arap, W., Pasqualini, R. & Ruoslahti, E. Science 279, 377–380 (1998).

    Article  CAS  Google Scholar 

  9. Horisawa, E. et al. Pharm. Res. 19, 132–139 (2002).

    Article  CAS  Google Scholar 

  10. Rehor, A., Hubbell, J. A. & Tirelli, N. Langmuir 21, 411–417 (2005).

    Article  CAS  Google Scholar 

Download references

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Setton, L. Reservoir drugs. Nature Mater 7, 172–174 (2008). https://doi.org/10.1038/nmat2130

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