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Rheumatoid arthritis

Circadian and circannual rhythms in RA

Nature Reviews Rheumatology volume 7, pages 500–502 (2011)Cite this article

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Early symptoms of arthritis either resolve spontaneously or progress into erosive disease; being able to predict the disease course would inform decisions about intensive early therapy. One predictive factor, according to a new multicenter study, is the season of first symptoms—so how does the Earth's movement influence disease progression?

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Figure 1: Clinical symptoms in patients with RA are influenced by the regular alternation of sunlight and darkness, in circadian and circannual biological rhythms.

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  1. School of Rheumatology, University of Genova, Viale Benedetto XV, 6, Genova, 16132, Italy

    Maurizio Cutolo

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  1. Maurizio Cutolo
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Cutolo, M. Circadian and circannual rhythms in RA. Nat Rev Rheumatol 7, 500–502 (2011). https://doi.org/10.1038/nrrheum.2011.115

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