Osteoarthritis (OA) is a heterogeneous group of diseases with different pathogenesis in different joints. What effect do metabolic factors, inflammation and obesity have on OA in non-loadbearing structures? A new study reports that, in the absence of knee OA, systemic processes are important in the pathogenesis of hand OA.
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Acknowledgements
A.E.W. is supported by an NHMRC Career Development Fellowship, Clinical level 2 (1063574).
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Cicuttini, F., Wluka, A. Is OA a mechanical or systemic disease?. Nat Rev Rheumatol 10, 515–516 (2014). https://doi.org/10.1038/nrrheum.2014.114
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DOI: https://doi.org/10.1038/nrrheum.2014.114
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