Abstract
The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.
MeSH terms
-
Animals
-
Carrier Proteins / immunology
-
Carrier Proteins / metabolism*
-
Embryonic and Fetal Development
-
Glycoproteins / immunology
-
Glycoproteins / metabolism*
-
Humans
-
Immune System / immunology
-
Lymph Nodes / growth & development*
-
Lymph Nodes / immunology
-
Membrane Glycoproteins / immunology
-
Membrane Glycoproteins / metabolism*
-
Osteoclasts / cytology*
-
Osteoclasts / metabolism
-
Osteoprotegerin
-
RANK Ligand
-
Receptor Activator of Nuclear Factor-kappa B
-
Receptors, Cytoplasmic and Nuclear*
-
Receptors, Tumor Necrosis Factor / immunology
-
Receptors, Tumor Necrosis Factor / metabolism*
Substances
-
Carrier Proteins
-
Glycoproteins
-
Membrane Glycoproteins
-
Osteoprotegerin
-
RANK Ligand
-
Receptor Activator of Nuclear Factor-kappa B
-
Receptors, Cytoplasmic and Nuclear
-
Receptors, Tumor Necrosis Factor
-
TNFRSF11A protein, human
-
TNFRSF11B protein, human
-
TNFSF11 protein, human