Abstract
The vertebral endplates are critical for maintaining disc function yet like other components of the disc are vulnerable to degeneration. This paper provides an overview of the development and normal function of the endplates as well as an impression of what happens when they undergo progressive degeneration. Recent research suggests that the degenerative process can be retarded or reversed.
MeSH terms
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Back Pain / etiology
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Back Pain / pathology
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Back Pain / physiopathology
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Cartilage / metabolism
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Cartilage / pathology
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Cartilage / physiopathology
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Disease Progression
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Extracellular Matrix / metabolism
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Humans
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Intervertebral Disc / pathology
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Intervertebral Disc / physiopathology*
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Microcirculation / physiopathology
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Regeneration* / physiology
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Spine / blood supply
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Spine / pathology
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Spine / physiopathology*