Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?

Dennis Lendrem; Sheryl Mitchell; Peter McMeekin; Luke Gompels; Katie Hackett; Simon Bowman; Elizabeth Price; Colin T Pease; Paul Emery; Jacqueline Andrews; Peter Lanyon; John Hunter; Monica Gupta; Michele Bombardieri; Nurhan Sutcliffe; Costantino Pitzalis; John McLaren; Annie Cooper; Marian Regan; Ian Giles; David Isenberg; Vadivelu Saravanan; David Coady; Bhaskar Dasgupta; Neil McHugh; Steven Young-Min; Robert Moots; Nagui Gendi; Mohammed Akil; Bridget Griffiths; Wan-Fai Ng; UK primary Sjögren’s Syndrome Registry

doi:10.1093/rheumatology/keu361

Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?

Rheumatology (Oxford). 2015 Apr;54(4):655-9. doi: 10.1093/rheumatology/keu361. Epub 2014 Sep 19.

Authors

Dennis Lendrem¹, Sheryl Mitchell², Peter McMeekin², Luke Gompels², Katie Hackett¹, Simon Bowman², Elizabeth Price², Colin T Pease², Paul Emery², Jacqueline Andrews², Peter Lanyon², John Hunter², Monica Gupta², Michele Bombardieri², Nurhan Sutcliffe², Costantino Pitzalis², John McLaren², Annie Cooper², Marian Regan², Ian Giles², David Isenberg², Vadivelu Saravanan², David Coady², Bhaskar Dasgupta², Neil McHugh², Steven Young-Min², Robert Moots², Nagui Gendi², Mohammed Akil², Bridget Griffiths², Wan-Fai Ng¹; UK primary Sjögren’s Syndrome Registry

Affiliations

¹ Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK. Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the
² Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.

PMID: 25240612
DOI: 10.1093/rheumatology/keu361

Abstract

Objective: This study sets out to investigate the relationship between health status [EuroQol five-dimensions questionnaire (EQ-5D)] in primary SS and three of the European League Against Rheumatism (EULAR) SS outcome measures-the disease activity index (ESSDAI), the patient reported index (ESSPRI) and the sicca score. In particular, the goal was to establish whether there is a relationship between the EULAR outcome measures and quality of life.

Methods: Health status was evaluated using a standardized measure developed by the EuroQol Group-the EQ5D. This permits calculation of two measures of health status: time trade-off (TTO) values and the EQ-5D visual analogue scale (VAS) scores. We used Spearman's rank correlation analysis to investigate the strength of association between health status and three EULAR measures of physician- and patient-reported disease activity in 639 patients from the UK primary SS registry (UKPSSR) cohort.

Results: This study demonstrates that the EULAR SS disease-specific outcome measures are significantly correlated with health outcome values (P < 0.001). Higher scores on the ESSDAI, EULAR sicca score and ESSPRI are associated with poorer health states-i.e. lower TTO values and lower VAS scores. While all three are significantly correlated with TTO values and EQ-5D VAS scores, the effect is strongest for the ESSPRI.

Conclusion: This study provides further evidence supporting the use of ESSDAI, EULAR sicca score and ESSPRI measures in the clinic. We also discuss the need for disease-specific measures of health status and their comparison with standardized health outcome measures.

Keywords: disease activity; outcome measures; patient-reported outcomes; primary Sjögren’s syndrome; quality of life; utility values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cohort Studies
Female
Health Status*
Humans
Male
Middle Aged
Outcome Assessment, Health Care
Patient Outcome Assessment
Quality of Life*
Severity of Illness Index
Sjogren's Syndrome / diagnosis*
Sjogren's Syndrome / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding