In the past few years considerable advances have been made in the genetics of
susceptibility to rheumatoid arthritis (RA). For decades the HLA-DRB1 alleles were the only …

Early treatment is associated with improved outcomes in patients with rheumatoid arthritis
(RA), suggesting that a'window of opportunity', in which the disease is most susceptible to …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Objective In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPA s) and
rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these …

Autoimmune responses against posttranslationally modified antigens are a hallmark of
several autoimmune diseases. For example, antibodies against citrullinated protein antigens …

Objective The main genetic risk factor for rheumatoid arthritis (RA), the HLA region, has
been known for 25 years. Previous research has demonstrated, within the RA population, an …

To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-
analysis of two published genome-wide association (GWA) studies totaling 3,393 cases and …

Objective During the last decade, rheumatologists have learned to initiate disease‐
modifying antirheumatic drugs (DMARDs) early to improve the outcome of rheumatoid …

Antibodies to citrullinated proteins (anti-cyclic-citrullinated peptide [anti-CCP] antibodies) are
highly specific for rheumatoid arthritis (RA) and precede the onset of disease symptoms …

To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P< 0.001 in a published meta-analysis of RA genome-wide …