Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …

Over the last few years, the power law distribution has been used as the data generating
mechanism in many disparate fields. However, at times the techniques used to fit the power …

Exposure to air pollution prematurely kills 7 million people globally every year. Policy
measures designed to reduce emissions of pollutants, improve ambient air and …

Ageing is a highly complex process; it involves interactions between numerous biochemical
and cellular mechanisms that affect many tissues in an organism. Although work on the …

Although stochastic population models have proved to be a powerful tool in the study of
process generating mechanisms across a wide range of disciplines, all too often the …

Purpose: This phase 1 dose escalation study evaluated the safety and feasibility of single-
dose intrapleural IFN-β gene transfer using an adenoviral vector (Ad. IFN-β) in patients with …

We previously showed that a single intrapleural dose of an adenoviral vector expressing
interferon-β (Ad. IFN-β) in patients with malignant pleural mesothelioma (MPM) or malignant …

PURPOSE: An endobronchial valve developed for treatment of severe emphysema has
characteristics favorable for bronchoscopic treatment of air leaks. We present the results of a …

Rationale: Most bronchoscopic procedures are performed using moderate sedation
achieved by combining a short-acting benzodiazepine with an opioid agent. Propofol (2.6 …