Ectopic lymphoid-like structures often develop at sites of inflammation where they influence
the course of infection, autoimmune disease, cancer and transplant rejection. These …

RA is a heterogeneous clinical and pathobiological entity. Specific pathways within synovial
tissues are emerging as associated with diverse clinical evolution and therapeutic …

Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

Lactate has long been considered a “waste” by-product of cell metabolism, and it
accumulates at sites of inflammation. Recent findings have identified lactate as an active …

Background Follicular structures resembling germinal centres (GCs) that are characterized
by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed …

Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …

Objective To investigate whether periosteal cells from adult humans have features of
multipotent mesenchymal stem cells (MSCs) at the single‐cell level. Methods Cell …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …