MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as
mediators of disease pathology via coordinated regulation of molecular effector pathways …

MicroRNA (miRNA) has the potential for cross-regulation and functional integration of
discrete biological processes during complex physiological events. Utilizing the common …

Galectin-3 is a β-galactoside-binding lectin that plays an important role in inflammatory
diseases. It also interacts with the surface carbohydrates of many pathogens, including LPS …

A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is
instrumental in shaping inflammatory responses. Recently, we and others have …

B1 B cells produce natural IgM and play a critical role in the early defense against bacterial
and viral infection. The polyreactive IgM also contributes to the clearance of apoptotic …

Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of
type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of …

Lymphatic endothelial cells are important for efficient flow of antigen-bearing fluid and
antigen-presenting cells (APCs) from peripheral sites to lymph nodes (LNs). APC movement …

Current treatments for rheumatoid arthritis (RA) do not reverse underlying aberrant immune
function. A genetic predisposition to RA, such as HLA-DR4 positivity, indicates that dendritic …

Tendon injuries (tendinopathies) are common in human and equine athletes and
characterized by dysregulated collagen matrix, resulting in tendon damage. We have …

LPS comprises a major PAMP and is a key target of the immune system during bacterial
infection. While LPS can be recognised by innate immune cells via the TLR4 complex, it is …