There is growing interest in the complex relationship between the nervous and immune
systems and how its alteration can affect homeostasis and result in the development of …

Nerve growth factor (NGF) levels are highly increased in inflamed tissues, but their role is
unclear. We show that NGF is part of a regulatory loop in monocytes: inflammatory stimuli …

The role of Interleukin (IL)-6 in the pathogenesis of joint and systemic inflammation in
rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis (s-JIA) has been clearly …

Objective To identify the role of mature nerve growth factor (mNGF), its immature form
proNGF and their receptors in arthritis inflammation. Methods Real-time PCR, western blot …

Mutations in the MLC1 gene, which encodes a protein expressed in brain astrocytes, are the
leading cause of MLC, a rare leukodystrophy characterized by macrocephaly, brain edema …

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare
leukodystrophy caused by mutations in the gene encoding MLC1, a membrane protein …

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare congenital
leukodystrophy characterized by macrocephaly, subcortical cysts and demyelination. The …

The present work aimed to explore the innovative hypothesis that different transcript/protein
variants of a pro-neurotrophin may generate different biological outcomes in a cellular …

We have recently provided new evidence for a role of p75NTR receptor and its preferential
ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of …

Background: Our previous studies 1 showed high expression levels of p75NTR, the nerve
growth factor (NGF) receptor, in mononuclear cells (MNCs) obtained from blood and …