User profiles for "author:Jeffrey N Miner"

Jeffrey N. Miner

Viscient Biosciences and Organovo
Verified email at viscientbio.com
Cited by 6851

The search for safer glucocorticoid receptor ligands

J Rosen, JN Miner - Endocrine reviews, 2005 - academic.oup.com
Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity.
However, despite their excellent efficacy, severe side effects frequently limit the use of these …

[HTML][HTML] Urate handling in the human body

D Hyndman, S Liu, JN Miner - Current rheumatology reports, 2016 - Springer
Elevated serum urate concentration is the primary cause of gout. Understanding the
processes that affect serum urate concentration is important for understanding the etiology of …

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element

MI Diamond, JN Miner, SK Yoshinaga, KR Yamamoto - Science, 1990 - science.org
The mechanism by which a single factor evokes opposite regulatory effects from a specific
DNA sequence is not well understood. In this study, a 25-base pair element that resides …

Regulatory crosstalk at composite response elements

JN Miner, KR Yamamoto - Trends in biochemical sciences, 1991 - cell.com
Steroid receptors and AP-1 factors function separately at their respective response
elements, and interact at cognate composite response elements. Diagrams of (a) nuclear …

The structural basis of androgen receptor activation: Intramolecular and intermolecular amino–carboxy interactions

F Schaufele, X Carbonell… - Proceedings of the …, 2005 - National Acad Sciences
Nuclear receptors (NRs) are ligand-regulated transcription factors important in human
physiology and disease. In certain NRs, including the androgen receptor (AR), ligand …

[HTML][HTML] Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

A Ives, J Nomura, F Martinon, T Roger, D LeRoy… - Nature …, 2015 - nature.com
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires
intracellular generation of reactive oxygen species (ROS). We present evidence that …

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

MJ Coghlan, PB Jacobson, B Lane… - Molecular …, 2003 - academic.oup.com
Glucocorticoids (GCs) are commonly used to treat inflammatory disease; unfortunately, the
long-term use of these steroids leads to a large number of debilitating side effects. The …

RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer

C Iverson, G Larson, C Lai, LT Yeh, C Dadson… - Cancer research, 2009 - AACR
The RAS-RAF-mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK)
kinase (MEK)-ERK pathway provides numerous opportunities for targeted oncology …

[HTML][HTML] Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

JN Miner, PK Tan, D Hyndman, S Liu, C Iverson… - Arthritis research & …, 2016 - Springer
Background Excess body burden of uric acid promotes gout. Diminished renal clearance of
uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter …

Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia

R Fleischmann, B Kerr, LT Yeh, M Suster, Z Shen… - …, 2014 - academic.oup.com
Objective. The aim of this study was to evaluate the pharmacodynamics (PDs),
pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption inhibitor) in …