DCs stimulated the growth and differentiation of CD4 New York, New York 10021 and CD8
alloreactive T cells, while, in the “efferent” phase, the activated T cells responded to other …

Fatigue is a complex phenomenon and an important health concern for many people with
chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis …

Sjögren's syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine
glands, leading to generalized mucosal dryness. However, primary SjS may initially present …

Despite thymic deletion of cells with specificity for self-antigens, autoreactive T cells are
readily detectable in the normal T-cell repertoire. In recent years, a population of CD4+ T …

Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …

The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in
recent decades: treatment decisions remain challenging in clinical practice, without a …

Objectives To define disease activity levels, minimal clinically important improvement (MCII)
and patient-acceptable symptom state (PASS) with the primary Sjögren's syndrome (SS) …

Abstract Objective. To reach a European consensus on the definition and characterization of
the main organ-specific extraglandular manifestations in primary SS. Methods. The EULAR …

Objectives To validate the two recently developed disease activity indexes for assessment of
primary Sjögren's syndrome (SS): the European League Against Rheumatism (EULAR) SS …

Objective To investigate whether rituximab, an anti–B cell therapy, improves symptoms of
fatigue and oral dryness in patients with primary Sjögren's syndrome (SS). Methods We …