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Obesity and inflammatory arthritis: impact on occurrence, disease characteristics and therapeutic response
  1. Claire I Daïen1 and
  2. Jérémie Sellam2
  1. 1Rheumatology Department, Teaching Hospital of Montpellier and UMR5535, CNRS, Institut de Génétique Moléculaire, Montpellier, France
  2. 2Rheumatology Department, Saint-Antoine Teaching Hospital, DHU i2B, Univ Paris 06, Paris and Inserm UMRS_938, Paris, France
  1. Correspondence to Claire I Daïen; c-daien{at}


Overweight and obesity are increasing worldwide and now reach about one-third of the world's population. Obesity also involves patients with inflammatory arthritis. Knowing the impact of obesity on rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis) is thus an important issue. This article first reviews the epidemiological and clinical data available on obesity in inflammatory rheumatic diseases, that is, its impact on incident disease, disease characteristics and the therapeutic response. The second part of this review gives an overview of the factors potentially involved in the specifics of inflammatory arthritis in patients with obesity, such as limitations in the clinical assessment, diet, microbiota and adipokines.

  • Psoriatic Arthritis
  • Rheumatoid Arthritis
  • Ankylosing Spondylitis

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