Article Text

Download PDFPDF

Review
EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide
  1. Raphaèle Seror1,
  2. Simon J Bowman2,
  3. Pilar Brito-Zeron3,
  4. Elke Theander4,
  5. Hendrika Bootsma5,
  6. Athanasios Tzioufas6,
  7. Jacques-Eric Gottenberg7,
  8. Manel Ramos-Casals3,
  9. Thomas Dörner8,
  10. Philippe Ravaud9,10,
  11. Claudio Vitali11,
  12. Xavier Mariette1 and
  13. on behalf of the EULAR Sjögren's Task Force
  1. Correspondence to Dr Raphaèle Seror; raphaele.se{at}gmail.com

Abstract

The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) is a systemic disease activity index that was designed to measure disease activity in patients with primary SS. With the growing use of the ESSDAI, some domains appear to be more challenging to rate than others. The ESSDAI is now in use as a gold standard to measure disease activity in clinical studies, and as an outcome measure, even a primary outcome measure, in current randomised clinical trials. Therefore, ensuring an accurate and reproducible rating of each domain, by providing a more detailed definition of each domain, has emerged as an urgent need. The purpose of the present article is to provide a user guide for the ESSDAI. This guide provides definitions and precisions on the rating of each domain. It also includes some minor improvement of the score to integrate advance in knowledge of disease manifestations. This user guide may help clinicians to use the ESSDAI, and increase the reliability of rating and consequently of the ability to detect true changes over time. This better appraisal of ESSDAI items, along with the recent definition of disease activity levels and minimal clinically important change, will improve the assessment of patients with primary SS and facilitate the demonstration of effectiveness of treatment for patients with primary SS.

  • Sjögren's Syndrome
  • Disease Activity
  • Outcomes research

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

View Full Text

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.