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The impact of patient heterogeneity and socioeconomic factors on abatacept retention in rheumatoid arthritis across nine European countries
  1. A Finckh1,2,
  2. D Neto2,
  3. F Iannone3,
  4. E Loza4,
  5. E Lie5,6,
  6. P van Riel7,
  7. M L Hetland8,9,
  8. K Pavelka10,
  9. J E Gottenberg11,
  10. H Canhão12,
  11. X Mariette13 and
  12. C Turesson14,15,16
  1. 1SCQM-RA, Switzerland
  2. 2Geneva University, Geneva, Switzerland
  3. 3GISEA, Rheumatology Unit, Interdisciplinary Department of Medicine, University of Bari, Italy
  4. 4BIOBADASER, Spain
  5. 5Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  6. 6NOR-DMARD, Norway
  7. 7DREAM, The Netherlands
  8. 8DANBIO, Center for Rheumatology and Spine Diseases,Rigshospitalet, Glostrup, Denmark
  9. 9Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  10. 10ATTRA, Czech Republic
  11. 11Department of Rheumatology, ORA, National Center for Rare Systemic Autoimmune Diseases, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, France
  12. 12REUMA.PT, Portugal
  13. 13ORA, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicetre, Université Paris-Sud, France
  14. 14ARTIS, Sweden
  15. 15Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
  16. 16Department of Rheumatology, Skåne University Hospital, Malmö, Sweden
  1. Correspondence to Axel Finckh; axel.finckh{at}hcuge.ch

Abstract

Background There are substantial differences in accessibility to biological disease modifying antirheumatic drugs (bDMARDs) across countries. The objective of this study was to analyse the impact of patient demographics, disease characteristics and gross domestic product (GDP) on abatacept (ABA) retention in patients with rheumatoid arthritis (RA) treated in clinical practice.

Methods Data from nine European observational RA cohorts of patients treated with ABA were pooled. Kaplan-Meier analysis was used to compare drug retention across registries. Specific causes of drug retention were investigated using competing risks multivariate Cox regression.

Results A total of 3961 patients treated with ABA, with 6188 patient-years of follow-up, were included. Patients in the different national registries had similar demographic features, but varied in baseline disease characteristics. ABA drug retention differed between countries, with median drug retention rates ranging from 1.2 to more than 6 years. The differences in drug retention were marginally explained by disparities in disease characteristics, while the national GDP per capita was strongly associated with drug retention (correlation coefficient −0.74; p=0.02).

Conclusions Patient characteristics at ABA initiation vary across Europe, probably reflecting differences in eligibility criteria and prescription patterns. However, the difference in ABA drug retention between countries was not primarily explained by disparities in patient characteristics. Lower ABA retention was observed in countries with a more liberal access to bDMARDs and higher GDP. National differences need to be accounted for when pooling data on treatment with bDMARDs from various countries.

  • DMARDs (biologic)
  • Rheumatoid Arthritis
  • Treatment

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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