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Tanaka Y. Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice. RMD Open 2023;9:e003270. doi: 10.1136/rmdopen-2023-003270
Updates have been made to the 2nd paragraph under the following section: Patients with moderate to severe SLE who are unable to achieve at least LLDAS with existing SoC treatments.
Original paragraph
In a post hoc analysis of the pooled TULIP-1/TULIP-2 trials, 15.3% of anifrolumab-treated patients (300 mg every 4 weeks (Q4W)) achieved DORIS remission at Week 52, compared with 7.6% of patients treated with placebo (odds ratio (OR) (95% CI): 2.2 (1.4 to 3.6), p=0.0013). DORIS remission was achieved by significantly more patients in the anifrolumab group compared with the placebo group starting at Week 32, suggesting an earlier attainment of DORIS remission with anifrolumab treatment.
Revised paragraph
In a post hoc analysis of the pooled TULIP-1/TULIP-2 trials, 15.3% of anifrolumab-treated patients (300 mg every 4 weeks (Q4W)) achieved DORIS remission at Week 52, compared with 6.6% of patients treated with placebo (odds ratio (OR) (95% CI): 2.6 (1.6 to 4.3), p=0.0002). DORIS remission was achieved by significantly more patients in the anifrolumab group compared with the placebo group starting at Week 32, suggesting an earlier attainment of DORIS remission with anifrolumab treatment.