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Osteoarthritis
Original article
Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
  1. Pauline Baudart1,2,
  2. Karine Louati1,3,4,
  3. Christian Marcelli2,5,6,7,
  4. Francis Berenbaum1,3,4,8 and
  5. Jérémie Sellam1,3,4,8
  1. 1Department of Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, Paris, France
  2. 2Department of Rheumatology, Caen Teaching Hospital, Caen, France
  3. 3Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France
  4. 4Sorbonne University, UPMC Univ Paris 06, Paris, France
  5. 5Normandy University, Caen, France
  6. 6UNICAEN, COMETE, Caen, France
  7. 7Inserm, U 1075 COMETE, Caen, France
  8. 8INSERM UMR_S938, Paris, France
  1. Correspondence to Dr Jérémie Sellam; jeremie.sellam{at}aphp.fr

Abstract

Objectives We aimed to investigate the prevalence of dyslipidemia in patients with osteoarthritis (OA) and whether OA and dyslipidemia are associated.

Methods We performed a systematic literature review and a meta-analysis, including cross-sectional, cohort and case–control studies, to assess the number of patients with OA and/or dyslipidemia. We calculated the mean (±SD) prevalence of dyslipidemia in patients with and without OA and the risk of dyslipidemia (OR, 95% CI) among patients with OA.

Results From 605 articles screened, 48 were included in the analysis (describing 29 cross-sectional, 10 cohort and 9 case–control studies). The mean prevalence of dyslipidemia was 30.2%±0.6% among 14 843 patients with OA and 8.0%±0.1% among 196 168 without OA. The risk of dyslipidemia was greater with than without OA overall (OR 1.98,95% CI 1.43 to 2.75, p<0.0001) and with knee OA (OR 2.27, 1.33 to 3.89, p=0.003) and hand OA (OR 2.12, 1.46 to 3.07), p<0.0001).

Conclusion The risk of dyslipidemia was twofold greater with than without OA, so lipid disturbances could be a risk factor for OA. Such a result supports the individualisation of the metabolic syndrome-associated OA phenotype.

  • Osteoarthritis
  • Dyslipidemia
  • Cholesterol
  • Metabolic Syndrome
  • Meta-analysis

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/rmdopen-2017-000442

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    Footnotes

    • Twitter @Larhumato

    • Contributors PB, KL, FB and JS were involved in conception and design. PB and KL were involved in acquisition of data and statistical analysis. PB, KL, CM, FB and JS were involved in analyses and interpretation of data, drafting of the manuscript, revision of the manuscript and final approval, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of data analysis.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement No additional data are available.